Photosensitizers are generally treated as key components for photodynamic therapy. In contrast, we herein report an aggregation-induced emission luminogen (AIEgen)-based photosensitizer (TPE-Py-FFGYSA) that can serve as a non-toxic adjuvant to amplify the antitumor efficacy of paclitaxel, a well-known anticancer drug, with a synergistic effect of “0 + 1 > 1”. Besides the adjuvant function, TPE-Py-FFGYSA can selectively light up EphA2 protein clusters overexpressed in cancer cells in a fluorescence turn-on mode, by taking advantage of the specific YSA peptide (YSAYPDSVPMMS)-EphA2 protein interaction. The simple incorporation of FFG as a self-assembly-aided unit between AIEgen (TPE-Py) and YSA significantly enhances the fluorescent signal output of TPE-Py when imaging EphA2 clusters in live cancer cells. Cytotoxicity and western blot studies reveal that the reactive oxygen species (ROS) generated by TPE-Py-FFGYSA upon exposure to light do not kill cancer cells, but instead provide an intracellular oxidative environment to help paclitaxel have much better efficacy. This study thus not only extends the application scope of photosensitizers, but also offers a unique theranostic system with the combination of diagnostic imaging and adjuvant antitumor therapy.
Chen Chao Zhegang Song Zheng Xiaoyan He Zikai Bin Liu Huang Xuhui Deling Kong Dan Ding 唐本忠
Chemical Science
2017
Fateminia Syed Mohammad Ali Wang Zhiming Goh Chiching Manghnani Purnima Naresh Wenbo Wu Mao Duo Ng Lai Guan Zujin Zhao 唐本忠 Bin Liu
Advanced Materials
2017
Pucci Andrea Leung Nelson L. C. Hor Andy Wu Shuizhu Gu Yuan Li Bingshi Liu Bin Hu Rongrong Anjun Qin Chen Xiaohong Li Zhen Zhang Deqing Krishnamoorthy Govindarajan Dario Pasini Tsuchiya Youichi Wang Kun He Xuewen Peng Huiqing Zhao Zujin He Gang 唐本忠 Eric Rivard Ito Fuyuki Tian He Zhu Ming-Qiang Jingzhi Sun Yoshiki Chujo Kuang Guichao Ma Yuguang Tian Wenjing Xu Bin Tsutsumi Osamu Duan Pengfei
Faraday Discussions
2017
Since the discovery of the aggregation-induced emission (AIE) phenomenon in 2001, research on AIE molecules has drawn much attention, and this area has been expanding tremendously. This brief review will focus on recent advances in the science and application of AIE molecules, including new mechanistic understanding, new AIE molecules for sensing and imaging, stimuli-responsive AIE molecules and applications of AIE molecules for OLEDs. Moreover, this review will give a perspective on the possible opportunities and challenges that exist in the future for this area.
Wang Yuancheng Zhang Guanxin Gao Meng Cai Yuanjing Zhan Chi Zujin Zhao Zhang Deqing 唐本忠
Faraday Discussions
2017
Leung Nelson L. C. Pucci Andrea Hu Rongrong Campbell Eleanor E. B. Krishnamoorthy Govindarajan 唐本忠 Wu Shuizhu Zhang Feng Mei Ju Bai Wei Li Bingshi He Xuewen Tang Youhong Liu Bin Zhang Ruoyu Wang Zhaoyang Anjun Qin Li Zhen Zhang Deqing Dario Pasini Tian Wenjing Tsuchiya Youichi Jadhav Thaksen Wang Yijia Zhao Zujin He Gang Li Kai Eric Rivard Zhu Ming-Qiang Xu Bin Sun Jing Zhi Yoshiki Chujo Hong Jin-Long Kong Lingwei Lu Ping Chang Cheng-Chung Wang Kun Singh Ram Adhar
Faraday Discussions
2017
Pucci Andrea Hor Andy Gao Meng Wu Shuizhu Yu Yunjian Li Bingshi He Xuewen Liu Bin Hu Rongrong Lou Xiaoding Li Zhen Krishnamoorthy Govindarajan Zhang Deqing Dario Pasini Tang Youhong Tsuchiya Youichi Wang Yijia Yuan Wang Zhang 唐本忠 Ding Dan Tian He Zhu Ming-Qiang Sun Jing Zhi Tian Wenjing Kuang Guichao Wu Luling Chen Junjian Zhang Ruoyu Jadhav Thaksen
Faraday Discussions
2017
For polymer materials, both their compositions and preparation process greatly influence their service performance. Thus, the sound understanding of the relationship between materials' preparation processes and their properties is paramount. However, current research methods are partially limited due to the absence of a direct testing method to track the entire process, e.g. synthesizing, curing, ageing, and so on. With the ability for real-time sensitive characterization, fluorescence spectroscopy may be applied in testing polymer materials' performance. Here, we synthesized a novel aggregation induced emission (AIE) resin named TPE-EPOXY resin and prepared an AIE coating based on it. According to restriction of intramolecular rotation (RIR) mechanism, the preparation, curing, and aging processes for the AIE polymer resins & coatings could be studied with real-time observation. In addition, their properties could also be studied systematically. The results in this paper pave a good way to understand the relationship between the internal structure and the properties of polymer materials. Moreover, the prepared AIE polymer resins has a potential to expand the application fields of the AIE mechanism.
Li Weili Yao Wei Wang Jun Qiu Zhenyu Tang Ji-Jun Shengyuan Yang 朱美芳 Xu Zexiao Hu Rong Anjun Qin 唐本忠
RSC Advances
2017
Organic fluorophores have attracted great interest owing to their wide applications. They usually contain an electron-conjugated system with an aromatic moiety and show high emission in dilute solutions but weaker or even no emission upon aggregation. Here, a simple one-pot, three-component reaction (3CR) (method I) for the synthesis of various di- and monosubstituted aminomaleimides (DAMIs and MAMIs) has been developed, and the reported 3CR (method II) has been found to be efficient only for the synthesis of MAMIs with R = alkyl. Twelve AMIs were designed and synthesized for investigation of the influence of structures on their optical properties in monomers and aggregates. It was found that alkyl MAMIs, alkyl DAMIs, and aryl AMIs/DAMIs show very different fluorescence efficiencies in different solvents, and only MAMIs with butyl and oleyl show high emissions in powders similar to those in nonpolar solutions. Single-crystal structures indicate that their fluorescence efficiencies in aggregates mainly correlate with molecular packing modes. The efficient synthesis method, the sensitive fluorescence on−off response to protic solvents or polar solvents, and the unusual high emissions of AMI without any aromatic moiety in both monomer and aggregates are expected to attract great interest in the fields of application and theory.
Zhu Qiuhua Ye Ziwei Yang Weijie Cai Xiaotie 唐本忠
Journal of Organic Chemistry
2017
Ferrocene-based polymers have drawn much attention in the past decades due to their unique properties and promising applications. However, the synthesis of hyperbranched polymers is still a great challenge. Here, two ferrocene-based hyperbranched polytriazoles with high molecular weights are facilely prepared by the click polymerization reactions of ferrocene-containing diazides (1) and tris(4-ethynylphenyl)amine (2) using Cu(PPh)Br as catalyst in dimethylformamide at 60 °C for 5 and 9 h in satisfactory yields of 54.0% and 52.3%. The resulting polytriazoles are soluble in common organic solvents and thermally stable, with 5% weight loss temperatures up to 307 °C. They can be used as precursors to produce nanostructured ceramics with good magnetizability by pyrolysis at elevated temperature. (Figure presented.).
李红坤 Chi Weiwen Liu Yajing Yuan Wei Yaowen Li 李永舫 唐本忠
Macromolecular Rapid Communications
2017
The development of new polymerization methodology is crucial for polymer materials. Alkyne polymerization based on versatile reactions of C=C bonds have attracted much attention recently because they can produce a great diversity of polymer materials with unsaturated structures and potential semiconducting properties. Among that, the polymerizations between alkyne and amine/amide which afford nitrogen-substituted alkynes with the triple bonds strongly polarized by the nitrogen atoms are quite attractive but challenging. In this work, the polycoupling of alkynyl bromides and sulfonamides is reported as the first example to generate polymers with stable N-C=C bonds in the polymer main chain. The polycoupling of various aromatic/aliphatic alkynyl bromides and sulfonamides can be carried out at mild condition in the presence of CuSO·5HO, 1,10-phenanthroline, and KCO at 65 °C under nitrogen, affording poly(ynesulfonamide)s with high molecular weights (up to 22000 g/mol) in high yields (up to 95%). Incorporation of luminescent tetraphenylethene structure into the alkynyl bromide monomer can produce polymer with aggregation-induced emission property and aggregated state fluorescence quantum efficiency of 24.7%. The plentiful C=C bonds of the polymers can serve as efficient ligands for organometallization with Co(CO) to generate organometallics, which can be further pyrolyzed to afford magnetic ceramics with high magnetic susceptibility (M up to 80.9 emu/g) and low coercivity (H down to 0.008 kOe). This new polycoupling reaction provides an efficient tool for the construction of polymer materials with unique N-C=C structures, which paves the way to advanced functionalities of polymers derived from ynesulfonamide structures.
Wu Xiuying Wei Bo 胡蓉蓉 唐本忠
Macromolecules
2017