【学术前沿】JMCB类器官专辑 | 精准搭建人体器官微模型

细胞世界

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类器官是一种由不同类型干细胞通过自组织方式制备，能够模拟原生器官结构和功能的一类三维“微器官模型”。相比传统的二维培养模型，类器官代表着一种能够概括整个生物体生理过程的创新技术，具有更接近生理细胞组成和行为、更稳定的基因组、更适合于生物转染和高通量筛选等优势。而与动物模型相比，类器官模型的操作更简单，还能用于研究疾病发生和发展等机理。

针对该领域的研究进展及应用潜力，Journal of Molecular Cell Biology (JMCB) 最新推出了类器官专辑。

Organoids: A Powerful Tool for Modeling Human Lives

Editorial│Modeling cellular polarity, plasticity, and disease disparity in 4D

Author: Xuebiao Yao

Perspective│Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions

Authors: Kim E. Boonekamp, Talya L. Dayton, Hans Clevers

Review│Organoid technology for tissue engineering

First Author: Juan He

Corresponding Author: Dong Gao

Keywords:

organoid, tissue engineering, 3D culture

Review│Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids

Authors: Fong Cheng Pan, Todd Evans, Shuibing Chen

Keywords:

human pluripotent stem cells, endoderm, gastrointestinal development, disease modeling

Review│Tumor organoids to study gastroesophageal cancer: a primer

Authors: Ramon U. Jin, Jason C. Mills

Keywords:

targeted therapy, precision oncology, cancer model, tumor heterogeneity, cancer evolution, personalized medicine

Review│Progress in human liver organoids

Authors: Lulu Sun, Lijian Hui

Keyword: liver organoid

Article│Generation of liver bipotential organoids with a small-molecule cocktail

First Authors: Xin Wang, Chao Ni

Corresponding Authors:

Bing Zhao, Xinhua Lin

Keywords:

liver bipotential organoid, small-molecule cocktail, long-term expansion, progenitor cell, hepatocyte differentiation, liver regeneration

Article│Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

First Author & Corresponding Author:

Yuhong Du

Keywords:

human colon organoids, KRASG12D, 3D culture, high-throughput screening (HTS), ultra-HTS (uHTS)

Article│In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

First Authors:

Tijmen H. Booij, Wouter N. Leonhard

Corresponding Author:

Dorien J. M. Peters

Keywords:

PKD, celastrol, pyrvinium pamoate, high-content screening, 3D

Article│Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly

First Authors: Xu Liu, Leilei Xu

Corresponding Authors:

Wenwen Wang, Xing Liu

Keywords:

organoids, cell division, central spindle, CENP-E, syntelin, PRC1

Highlight│Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics

Authors: Lauretta A. Lacko, Shuibing Chen

来源：JMCB学术前沿

1980-2020

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