“凡两个物体接触，必会产生转移现象”--罗卡交换定律。
这个定律是说，只要是犯罪现场，犯罪嫌疑人和受害者必定会留下一些物证，而这些细微的物证往往会成为决定性的证据。
在犯罪现场，DNA是最有信服力的物证之一。从现场残留的微量的生物组织样本（血液、毛发、皮屑、精液等等）中提取DNA，与犯罪嫌疑人的进行比对，如果一致，那么很大概率此嫌犯就是真凶。
![]()
图片来源：www.sciencemag.org/news
![]()
什么是表观遗传？
![]()
什么是DNA甲基化？
![]()
![]()
DNA甲基化对基因表达的调控 图片来源：作者提供
![]()
如何用DNA甲基化来预测年龄？
![]()
![]()
医学生命科学检索引擎pubmed上搜索“DNA methylation age estimation（DNA甲基化 年龄预测）”得到的历年文献数量的变化图（横轴为年份，竖轴为文献数量）图片来源：作者提供
![]()
除了人类，年龄预测还可以应用于何处？
![]()
![]()
图片来源：pexels
![]()
【1】Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome biology, 14(10), 3156.【2】Zbieć-Piekarska, R., Spólnicka, M., Kupiec, T., Makowska, Ż., Spas, A., Parys-Proszek, A., ... & Branicki, W. (2015). Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science. Forensic Science International: Genetics, 14, 161-167.【3】Correia Dias, H., Cordeiro, C., Corte Real, F., Cunha, E., & Manco, L. (2020). Age Estimation Based on DNA Methylation Using Blood Samples From Deceased Individuals. Journal of Forensic Sciences, 65(2), 465-470.【4】Thompson, M. J. (2017). An epigenetic aging clock for dogs and wolves. Aging (Albany NY), 9(3), 1055.【5】Tung, J., Anderson, J., Johnston, R., Alberts, S., Archie, E., & Campos, F. (2020). The costs of competition: high social status males experience accelerated epigenetic aging in wild baboons. bioRxiv.【6】Polanowski, A. M., Robbins, J., Chandler, D., & Jarman, S. N. (2014). Epigenetic estimation of age in humpback whales. Molecular ecology resources, 14(5), 976-987.【7】Wright, P. G., Mathews, F., Schofield, H., Morris, C., Burrage, J., Smith, A., ... & Hamilton, P. B. (2018). Application of a novel molecular method to age free‐living wild Bechstein's bats. Molecular ecology resources, 18(6), 1374-1380.【8】Ito, H., Udono, T., Hirata, S., & Inoue-Murayama, M. (2018). Estimation of chimpanzee age based on DNA methylation. Scientific reports, 8(1), 1-5.【9】Little, T. J., O'toole, A. N., Rambaut, A., Chandra, T., Marioni, R., & Pedersen, A. B. (2020). Methylation-Based Age Estimation in a Wild Mouse. BioRxiv.![]()
点亮 ![]()
，告诉大家你也在看![]()