近日,Journal of Materials Chemistry B 副主编、Biomaterials Science 顾问委员会成员、日本国立材料科学研究所陈国平教授精选了近期发表在两本期刊上的“微流控”领域综述和研究论文,欢迎点击文末阅读原文查看合辑中的精彩论文。
微流控技术使用流体微通道在微米层级上操控多种流体。由于其独特的微型化特性,微流控技术相较于常规技术拥有诸多优势。微流控手段和微流控设备已被广泛用于生物医学领域,包括药物输送、微载体、诊断、生物传感、生物成像、器官芯片、细胞分离和细胞包封等。
Journal of Materials Chemistry B 发表具有生物学和医学应用潜力的材料的性质与合成研究,特别强调工作在材料化学上的进步。Biomaterials Science 重点关注的工作是对生物材料背后科学原理的理解以及生物材料在生物环境下的性能报道。
来自上述两本期刊的合辑论文涵盖微珠制备、器官芯片、细胞封装、生物传感和生物测量等诸多课题。
Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells
Pi Ding, Zhili Wang, Zeen Wu, Weipei Zhu, Lifen Liu, Na Sun and Renjun Pei
This paper summarizes various aptamer-functionalized nanostructured interfaces for the detection and release of circulating tumor cells.
通讯作者:孙娜(中国科学院苏州纳米技术与纳米仿生研究所)、裴仁军(中国科学院苏州纳米技术与纳米仿生研究所)
J. Mater. Chem. B, 2020, 8, 3408-3422
http://doi.org/10.1039/C9TB02457C
Advances in functional nucleic acid based paper sensors
Rudi Liu, Erin M. McConnell, Jiuxing Li and Yingfu Li
This article provides an extensive review of paper-based sensors that utilize functional nucleic acids, particularly DNA aptamers and DNAzymes, as recognition elements.
通讯作者:李应福(麦克马斯特大学)
J. Mater. Chem. B, 2020, 8, 3213-3230
http://doi.org/10.1039/C9TB02584G
PLGA/chitosan–heparin composite microparticles prepared with microfluidics for the construction of hMSC aggregates
Min Ge, Yaqi Sheng, Shuyue Qi, Lei Cao, Yan Zhang and Jun Yang
P/C–h composite microparticles fabricated by microfluidics enhanced the biological functions of hMSC aggregates through neutralizing PLGA′ acidic degradation products.
通讯作者:张燕(南开大学)、杨军(南开大学)
J. Mater. Chem. B, 2020, 8, 9921-9932
http://doi.org/10.1039/D0TB01593H
One-step synthesis of composite hydrogel capsules to support liver organoid generation from hiPSCs
Yaqing Wang, Haitao Liu, Min Zhang, Hui Wang, Wenwen Chen and Jianhua Qin
One-step synthesis of composite hydrogel capsules (CHCs) that allow engineering hiPSC-derived liver organoids in an oil-free droplet microfluidic system.
通讯作者:秦建华(中国科学院大连化学物理研究所)
Biomater. Sci., 2020, 8, 5476-5488
http://doi.org/10.1039/D0BM01085E
Colorimetric detection of urine glucose using a C/CdTe QDs–GOx aerogel based on a microfluidic assay sensor
Tao Hu, Kangkai Xu, Shanhu Qiu, Yu Han, Juan Chen, Jian Xu, Ke Chen, Zilin Sun, Hong Yi and Zhonghua Ni
A sensitive fluorescent microfluidic sensor based on carbon quantum dots (CQDs), cadmium telluride quantum dots (CdTe QDs) aerogel and glucose oxidase (GOx) for urinal glucose detection was fabricated via a simple method.
通讯作者:孙子林(东南大学)、易红(东南大学)、倪中华(东南大学)
J. Mater. Chem. B, 2020, 8, 7160-7165
http://doi.org/10.1039/D0TB00328J
A microfluidics-derived growth factor gradient in a scaffold regulates stem cell activities for tendon-to-bone interface healing
Jingtong Lyu, Long Chen, Jiqiang Zhang, Xia Kang, Yunjiao Wang, Wenjie Wu, Hong Tang, Jun Wu, Zhiyu He and Kanglai Tang
Treatment of tendon-to-bone interface injury has long been challenging in sports medicine.
通讯作者:吴钧(中山大学)、何治宇(中国海洋大学)、唐康来(第三军医大学)
Biomater. Sci., 2020, 8, 3649-3663
http://doi.org/10.1039/D0BM00229A
Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy
Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang and Wei Chen
Illustration of pH-degradable microgels (MGs) for the simultaneous encapsulation of OA and JQ1 for an enhanced oncolytic viral treatment with JQ1-meidated boosting viral replication and PD-L1 suppression.
通讯作者:钟伊南(中国药科大学)、唐奇(南京医科大学)、陈维(中国药科大学)
Biomater. Sci., 2020, 8, 2472-2480
http://doi.org/10.1039/D0BM00172D
报道生物材料科学的研究进展及其向临床应用的转化。论文范围包括生物材料设计中的新概念,生物材料与生物体相互作用的研究以及使用材料来解决生物学问题的方法。所报道的生物材料并不必须是首次发表,但需要对该生物材料的生物学应用提出新颖的见解(例如组织工程、再生医学、治疗剂输送或仿生材料等)。该刊也是欧洲生物材料学会的会刊。
Journal of Materials Chemistry A、B 和 C 报道材料化学各领域的高质量理论或实验研究工作。这三本期刊发表的论文侧重于报道对材料及其性质的新理解、材料的新应用以及材料合成的新方法。Journal of Materials Chemistry A、B 和 C 的区别在于所报道材料的不同预期用途。粗略的划分是,Journal of Materials Chemistry A 报道材料在能源和可持续性方面的应用,Journal of Materials Chemistry B 报道材料在生物学和医学方面的应用,Journal of Materials Chemistry C 报道材料在光学、磁学和电子设备方面的应用。