推荐阅读文章 | 链霉菌CB02959中四霉素及四烯菌素的鉴定及培养基优化

图1  纳他霉素、四霉素和四烯菌素的结构

Figure 1  Chemical structures of Natamycin, Tetramycins and Tetrins

图2  Streptomyces sp.CB02959中四霉素基因簇及纳他霉素基因簇比较

Figure 2  Comparison of the tetramycin biosynthetic gene cluster from Streptomyces sp.CB02959 with gene clusters from selected tetramycin and natamycin producers

图3  基于16S rRNA基因序列的纳他霉素和四霉素产生菌株的系统进化树

Figure 3  Phylogenetic analysis of natamycin and tetramycin-producing strains based on 16S rRNA gene sequence

图4  CB02959在不同发酵培养基中的HPLC图谱(A)以及化合物1–4的紫外吸收谱图(B) 

Figure 4  HPLC profiles of CB02959 in different fermentation media (A) and the UV-vis spectrum (B) for compound 1–4

图5  CB02959 ΔtetrA突变株的构建及发酵验证

Figure 5  Generation and fermentation verification of CB02959 ΔtetrA mutant

图6  CB02959中化合物1–4产量的初步发酵优化

Figure 6  Preliminary fermentation optimization of compounds 1–4 from CB02959

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本期制作：赵彬涵