刘兴国团队发现线粒体膜间隙的分子伴侣

2021年8月31日, Science China Life Sciences（《中国科学：生命科学》英文版）在线发表了中国科学院广州生物医药与健康研究院刘兴国团队的最新研究成果“Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space”的研究论文，该研究报道了在线粒体这一双膜细胞器中，内外膜之间的膜间隙是来自呼吸链多重损伤的最恶劣胁迫区域，而OPA1的可溶性短链蛋白在这一区域起到分子伴侣（molecular chaperon）帮助蛋白折叠这一全新功能，对于维持线粒体稳态发挥重要作用。

【参考文献】

Li, L., Chen, K., Wang, T., Wu, Y., Xing, G., Chen, M., Hao, Z., Zhang, C., Zhang, J., Ma, B., Liu, Z., Yuan, H., Liu, Z., Long, Q., Zhou, Y., Qi, J., Zhao, D., Gao, M., Pei, D., Nie, J., Ye, D., Pan, G., & X. Liu*. (2020, 2020/09/01). Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade. Nature Metabolism, 2(9), 882-892. https://doi.org/10.1038/s42255-020-0267-9

Li, S., Guo, J., Ying, Z., Chen, S., Yang, L., Chen, K., Long, Q., Qin, D., Pei, D., & X. Liu*. (2015). Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5), 1730-1739. https://doi.org/https://doi.org/10.1002/hep.27712

Liu, X., Weaver, D., Shirihai, O., & Hajnóczky, G. (2009, 2009/10/21). Mitochondrial ‘kiss-and-run’: interplay between mitochondrial motility and fusion–fission dynamics [https://doi.org/10.1038/emboj.2009.255]. The EMBO Journal, 28(20), 3074-3089. https://doi.org/https://doi.org/10.1038/emboj.2009.255

Wu, Y., Chen, K., Xing, G., Li, L., Ma, B., Hu, Z., Duan, L., & X. Liu*. (2019, Nov). Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Sci Adv, 5(11), eaax7525. https://doi.org/10.1126/sciadv.aax7525

Yang, L., Tang, H., Lin, X., Wu, Y., Zeng, S., Pan, Y., Li, Y., Xiang, G., Lin, Y. F., Zhuang, S. M., Song, Z., Jiang, Y., & X. Liu*. (2020). OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion. Front Cell Dev Biol, 8, 180. https://doi.org/10.3389/fcell.2020.00180

Yao, D., Y. Li, S. Zeng, Z. Li, Z. Shah, B. Song, J. Liu, Y. Wu, L. Yang, Q. Long, W. Wang, Z. Hu, H. Tang, & X. Liu* (2021) Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space. SCIENCE CHINA Life Sciences Aug 01, 2021, online. https://doi.org/10.1007/s11427-021-1962-0

Ying, Z., Chen, K., Zheng, L., Wu, Y., Li, L., Wang, R., Long, Q., Yang, L., Guo, J., Yao, D., Li, Y., Bao, F., Xiang, G., Liu, J., Huang, Q., Wu, Z., Hutchins, Andrew P., Pei, D., & X. Liu*. (2016, 2016/01/12/). Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming. Cell Metabolism, 23(1), 220-226. https://doi.org/https://doi.org/10.1016/j.cmet.2015.10.002 

Ying, Z., Xiang, G., Zheng, L., Tang, H., Duan, L., Lin, X., Zhao, Q., Chen, K., Wu, Y., Xing, G., Lv, Y., Li, L., Yang, L., Bao, F., Long, Q., Zhou, Y., He, X., Wang, Y., Gao, M., Pei, D., Chan, W.-Y., & X. Liu*. (2018, 2018/12/04/). Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming. Cell Metabolism, 28(6), 935-945.e935. https://doi.org/https://doi.org/10.1016/j.cmet.2018.08.001