大剂量激素治疗“炎症风暴”遭质疑
寻找炎症关键细胞因子被关注
促炎细胞因子IL-6是
诱发炎症风暴的重要通路
双歧杆菌三联活菌制剂可
抑制促炎细胞因子分泌
降低血液中IL-6水平
双歧杆菌三联活菌制剂
可促进免疫调节
小结
参考文献:
1. Russell CD, Millar JE, Baillie JK.Clinical evidence does not support corticosteroid treatment for 2019-nCoV lunginjury. The Lancet 2020;
2. WHO. Clinical management of severe acuterespiratory infection when novel coronavirus (nCoV) infection is suspected.Geneva: World Health Organization, Jan 28, 2020.
3. Shi C Z , Chen H Q , Liang Y , et al. Combined probiotic bacteria promotes intestinal epithelial barrier function in interleukin-10-gene-deficient mice[J]. World Journal of Gastroenterology, 2014, 20(16):4636-4647.
4. Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice[J]. World Journal of Gastroenterology, 2013(05):150-157.
5. Cui H H , Chen C L , Wang J D , et al. Effects of probiotic on intestinal mucosa of patients with ulcerative colitis[J]. World Journal of Gastroenterology, 2004, 10(10):p.1521-1525.
6. Samah S, et al. Diabetes Res Clin Pract 2016 - Review.Probiotics for the management of type 2 diabetes mellitus: A systematic review and meta-analysis.
7. Mohammed AT, et al. Clin Rheumatol 2017 - Review.The therapeutic effect of probiotics on rheumatoid arthritis: a systematic review and meta-analysis of randomized control trials.
8. Jiang C , Wang H , Xia C , et al. A randomized, double-blind, placebo-controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma[J]. Cancer, 2018.
9.鲁艳, 程利民, 方木平, et al. 双歧杆菌三联活菌散对婴幼儿湿疹肠道菌群、免疫功能及细胞因子的影响[J]. 儿科药学杂志, 2015(10):17-19.
10.张茜. 益生菌辅助糖皮质激素制剂治疗小儿湿疹的临床研究[J]. 数理医药学杂志, 2017(4).
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