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  • Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity

    • 摘要:

      While the search for an efficacious HIV-1 vaccine remains elusive, emergence of a new generation of virus-neutralizing monoclonal antibodies (mAbs) has re-ignited the field of passive immunization for HIV-1 prevention. However, the plasticity of HIV-1 demands additional improvements to these mAbs to better ensure their clinical utility. Here, we report engineered bispecific antibodies that are the most potent and broad HIV-neutralizing antibodies to date. One bispecific antibody, 10E8/iMab, neutralized 118 HIV-1 pseudotyped viruses tested with a mean 50% inhibitory concentration (IC) of 0.002 μg/mL. 10E8/iMab also potently neutralized 99% of viruses in a second panel of 200 HIV-1 isolates belonging to clade C, the dominant subtype accounting for ∼50% of new infections worldwide. Importantly, 10E8/iMab reduced virus load substantially in HIV-1-infected humanized mice and also provided complete protection when administered prior to virus challenge. These bispecific antibodies hold promise as novel prophylactic and/or therapeutic agents in the fight against HIV-1.

    • 作者:

      Huang Yaoxing    Yu Jian    Lanzi Anastasia    Yao Xin    Andrews Chasity D.    Tsai Lily    Gajjar Mili R.    Sun Ming    Michael Seaman    Padte Neal N.    何大一    

    • 刊名:

      Cell

    • 在线出版时间:

      2016