Uric acid induces renal inflammation via activating tubular NF-κB signaling pathway

Yang Zhou;Li Fang;雷 江;Ping Wen;Hongdi Cao;Weichun He;Chunsun Dai;Junwei Yang

Nanjing Medical University

发表时间:2012-6-25

期 刊:PLoS ONE

语 言:English

U R L: http://www.scopus.com/inward/record.url?scp=84862665366&partnerID=8YFLogxK

摘要

Inflammation is a pathologic feature of hyperuricemia in clinical settings. However, the underlying mechanism remains unknown. Here, infiltration of T cells and macrophages were significantly increased in hyperuricemia mice kidneys. This infiltration of inflammatory cells was accompanied by an up-regulation of TNF-α, MCP-1 and RANTES expression. Further, infiltration was largely located in tubular interstitial spaces, suggesting a role for tubular cells in hyperuricemia-induced inflammation. In cultured tubular epithelial cells (NRK-52E), uric acid, probably transported via urate transporter, induced TNF-α, MCP-1 and RANTES mRNA as well as RANTES protein expression. Culture media of NRK-52E cells incubated with uric acid showed a chemo-attractive ability to recruit macrophage. Moreover uric acid activated NF-κB signaling. The uric acid-induced up-regulation of RANTES was blocked by SN 50, a specific NF-κB inhibitor. Activation of NF-κB signaling was also observed in tubule of hyperuricemia mice. These results suggest that uric acid induces renal inflammation via activation of NF-κB signaling.

相关科学

农业与生物科学
生物化学、遗传学和分子生物学

文献指纹

农业与生物学

chemokine CCL5

hyperuricemia

uric acid

inflammation

kidneys

1-methylcyclopropene

macrophages

mice

cultured cells

cells

T-lymphocytes

transporters

epithelial cells

protein synthesis

culture media

化合物

Uric Acid

Chemokine CCL5

Infiltration

Macrophages

Chemical activation

urate transporter

Epithelial Cells

T-cells

Culture Media

Messenger RNA

Proteins

医学与生命科学

Uric Acid

Chemokine CCL5

Hyperuricemia

Inflammation

Kidney

urate transporter

Up-Regulation

Macrophages

Culture Media

Epithelial Cells

T-Lymphocytes

Messenger RNA

Proteins

被引量

期刊度量

Scopus度量

年份 CiteScore SJR SNIP
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007 1.379 0.543
2008 2.506 1.009
2009 2.614 1.059
2010 2.705 1.193
2011 4.5 2.425 1.253
2012 4.1 1.982 1.17
2013 4.4 1.772 1.162
2014 5.1 1.559 1.151
2015 5.6 1.427 1.15
2016 5.9 1.236 1.124
2017 5.7 1.164 1.149
2018 5.4 1.1 1.167
2019 5.2 1.023 1.205
2020 5.3
2021

相似文献推荐