Yang Zhou;Li Fang;雷 江;Ping Wen;Hongdi Cao;Weichun He;Chunsun Dai;Junwei Yang
Nanjing Medical University
发表时间:2012-6-25
期 刊:PLoS ONE
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=84862665366&partnerID=8YFLogxK
Inflammation is a pathologic feature of hyperuricemia in clinical settings. However, the underlying mechanism remains unknown. Here, infiltration of T cells and macrophages were significantly increased in hyperuricemia mice kidneys. This infiltration of inflammatory cells was accompanied by an up-regulation of TNF-α, MCP-1 and RANTES expression. Further, infiltration was largely located in tubular interstitial spaces, suggesting a role for tubular cells in hyperuricemia-induced inflammation. In cultured tubular epithelial cells (NRK-52E), uric acid, probably transported via urate transporter, induced TNF-α, MCP-1 and RANTES mRNA as well as RANTES protein expression. Culture media of NRK-52E cells incubated with uric acid showed a chemo-attractive ability to recruit macrophage. Moreover uric acid activated NF-κB signaling. The uric acid-induced up-regulation of RANTES was blocked by SN 50, a specific NF-κB inhibitor. Activation of NF-κB signaling was also observed in tubule of hyperuricemia mice. These results suggest that uric acid induces renal inflammation via activation of NF-κB signaling.
农业与生物学
化合物
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | |||
2003 | |||
2004 | |||
2005 | |||
2006 | |||
2007 | 1.379 | 0.543 | |
2008 | 2.506 | 1.009 | |
2009 | 2.614 | 1.059 | |
2010 | 2.705 | 1.193 | |
2011 | 4.5 | 2.425 | 1.253 |
2012 | 4.1 | 1.982 | 1.17 |
2013 | 4.4 | 1.772 | 1.162 |
2014 | 5.1 | 1.559 | 1.151 |
2015 | 5.6 | 1.427 | 1.15 |
2016 | 5.9 | 1.236 | 1.124 |
2017 | 5.7 | 1.164 | 1.149 |
2018 | 5.4 | 1.1 | 1.167 |
2019 | 5.2 | 1.023 | 1.205 |
2020 | 5.3 | ||
2021 |
相似文献推荐