Yang Liu;雪涛 曹
Chinese Academy of Medical Sciences;China Association for Science and Technology
发表时间:2016-11-14
期 刊:Cancer Cell
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=85006375075&partnerID=8YFLogxK
Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can be primed and established through a complex interplay among primary tumor-derived factors, tumor-mobilized bone marrow-derived cells, and local stromal components. We review here our current understanding of the key components and underlying mechanisms for pre-metastatic niche formation. We propose six characteristics that define the pre-metastatic niche, which enable tumor cell colonization and promote metastasis, including immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, and reprogramming. We highlight the significance of the pre-metastatic niche, and discuss potential implications and future research directions.
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | |||
2003 | 9.46 | 2.445 | |
2004 | 11.168 | 2.781 | |
2005 | 11.785 | 2.723 | |
2006 | 12.358 | 3.276 | |
2007 | 12.992 | 3.742 | |
2008 | 15.652 | 4.408 | |
2009 | 15.159 | 4.558 | |
2010 | 16.468 | 4.669 | |
2011 | 40 | 16.203 | 4.749 |
2012 | 42.4 | 16.267 | 4.92 |
2013 | 43.9 | 17.638 | 4.933 |
2014 | 40.4 | 14.883 | 4.632 |
2015 | 41.7 | 13.74 | 4.934 |
2016 | 40.3 | 13.509 | 5.089 |
2017 | 44.3 | 12.7 | 4.877 |
2018 | 37.8 | 11.741 | 4.691 |
2019 | 40.7 | 11.909 | 5.086 |
2020 | 37 |
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