Yi Han Chen;Shi Jie Xu;Saïd Bendahhou;Xiao Liang Wang;Ying Wang;Wen Yuan Xu;Hong Wei Jin;Hao Sun;Xiao Yan Su;Qi Nan Zhuang;Yi Qing Yang;Yue Bin Li;Yi Liu;Hong Ju Xu;Xiao Fei Li;Ning Ma;Chun Ping Mou;竺 陈;Jacques Barhanin;Wei Huang
Tongji University;Chinese National Human Genome Center at Shanghai;Chinese Academy of Sciences;Université Blaise Pascal;Institute of Materia Medica; Chinese Academy of Medical Sciences & Peking Union Medical College;China Association for Science and Technology;Ruijin Hospital
发表时间:2003-1-10
期 刊:Science
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0037428218&partnerID=8YFLogxK
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with hereditary persistent AF and identified the causative mutation (S140G) in the KCNQ1 (KvLQT1) gene on chromosome 11p15.5. The KCNQ1 gene encodes the pore-forming α subunit of the cardiac IKs channel (KCNQ1/KCNE1), the KCNQ1/KCNE2 and the KCNQ1/KCNE3 potassium channels. Functional analysis of the S140G mutant revealed a gain-of-function effect on the KCNQ1/KCNE1 and the KCNQ1/ KCNE2 currents, which contrasts with the dominant negative or loss-of-function effects of the KCNQ1 mutations previously identified in patients with long QT syndrome. Thus, the S140G mutation is likely to initiate and maintain AF by reducing action potential duration and effective refractory period in atrial myocytes.
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 16.615 | 6.948 | |
2000 | 13.319 | 7.003 | |
2001 | 10.987 | 6.898 | |
2002 | 10.814 | 7.242 | |
2003 | 11.428 | 7.439 | |
2004 | 11.589 | 7.237 | |
2005 | 11.09 | 6.525 | |
2006 | 10.542 | 6.097 | |
2007 | 10.072 | 5.991 | |
2008 | 11.277 | 6.041 | |
2009 | 11.897 | 7.025 | |
2010 | 13.481 | 7.745 | |
2011 | 44.7 | 14.238 | 8.191 |
2012 | 46.3 | 13.318 | 7.992 |
2013 | 46.9 | 12.41 | 7.719 |
2014 | 46 | 12.052 | 8.045 |
2015 | 46.6 | 12.872 | 7.549 |
2016 | 49.5 | 13.745 | 7.652 |
2017 | 49.4 | 14.142 | 7.366 |
2018 | 47.1 | 13.251 | 7.529 |
2019 | 45.3 | 13.11 | 7.521 |
2020 | 40.2 |
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