A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin;Ruiqiang Li;Jeroen Raes;Manimozhiyan Arumugam;Kristoffer Solvsten Burgdorf;Chaysavanh Manichanh;Trine Nielsen;Nicolas Pons;Florence Levenez;Takuji Yamada;Daniel R. Mende;Junhua Li;Junming Xu;Shaochuan Li;Dongfang Li;Jianjun Cao;Bo Wang;Huiqing Liang;Huisong Zheng;Yinlong Xie;Julien Tap;Patricia Lepage;Marcelo Bertalan;Jean Michel Batto;Torben Hansen;Denis Le Paslier;Allan Linneberg;H. Bjørn Nielsen;Eric Pelletier;Pierre Renault;Thomas Sicheritz-Ponten;Keith Turner;Hongmei Zhu;Chang Yu;Shengting Li;Min Jian;Yan Zhou;Yingrui Li;Xiuqing Zhang;Songgang Li;Nan Qin;焕明 杨;Jian Wang;Søren Brunak;Joel Doré;Francisco Guarner;Karsten Kristiansen;Oluf Pedersen;Julian Parkhill;Jean Weissenbach;Peer Bork;S. Dusko Ehrlich;军 王;Maria Antolin;François Artiguenave;Hervé Blottiere;Natalia Borruel;Thomas Bruls;Francesc Casellas;Christian Chervaux;Antonella Cultrone;Christine Delorme;Gérard Denariaz;Rozenn Dervyn;Miguel Forte;Carsten Friss;Maarten Van De Guchte;Eric Guedon;Florence Haimet;Alexandre Jamet;Catherine Juste;Ghalia Kaci;Michiel Kleerebezem;Jan Knol;Michel Kristensen;Severine Layec;Karine Le Roux;Marion Leclerc;Emmanuelle Maguin;Raquel Melo Minardi;Raish Oozeer;Maria Rescigno;Nicolas Sanchez;Sebastian Tims;Toni Torrejon;Encarna Varela;Willem De Vos;Yohanan Winogradsky;Erwin Zoetendal

CAS - Beijing Institute of Genomics;European Molecular Biology Laboratory;Vrije Universiteit Brussel;Novo Nordisk A/S;University of Barcelona;INRAE;South China University of Technology;Shenzhen University;Technical University of Denmark;CEA;Research Center for Prevention and Health;Wellcome Sanger Institute;China Association for Science and Technology;University of Copenhagen;Commissariatà L Energie Atomique;Danone S.A.;UCB S.A.;Wageningen Unviersiteit;IRCCS Istituto Europeo di Oncologia - Milano

发表时间:2010

期 刊:Nature

语 言:English

U R L: http://www.scopus.com/inward/record.url?scp=77950251400&partnerID=8YFLogxK

摘要

To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, 150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively.

文献指纹

农业与生物学

intestinal microorganisms

digestive system

genes

human health

complement

microorganisms

genome

bacteria

sampling

被引量

期刊度量

Scopus度量

年份 CiteScore SJR SNIP
1996
1997
1998
1999 15.599 7.183
2000 11.917 6.845
2001 9.874 6.735
2002 10.114 7.208
2003 11.384 7.504
2004 11.222 7.523
2005 10.333 7.199
2006 9.702 7.156
2007 10.344 7.097
2008 13.17 7.321
2009 15.185 8.2
2010 16.465 8.23
2011 53.1 17.598 8.652
2012 51 17.546 8.409
2013 50.9 19.69 8.482
2014 49.9 18.78 7.946
2015 51.6 19.669 8.052
2016 49.2 18.389 7.901
2017 53.7 17.875 8.647
2018 55.7 16.345 9.448
2019 51 14.047 8.82
2020 49.5

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