一公 施;Yan Fel Wang;Lata Jayaraman;Haijuan Yang;Joan Massagué;Nikola P. Pavletich
Princeton University;Howard Hughes Medical Institute
发表时间:1998-9-4
期 刊:Cell
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0032483544&partnerID=8YFLogxK
The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-β signaling from cell membrane to nucleus. The crystal structure of a Smad3 MH1 domain bound to an optimal DNA sequence determined at 2.8 Å resolution reveals a novel DNA-binding motif. In the crystals, base-specific DNA recognition is provided exclusively by a conserved 11-residue β hairpin that is embedded in the major groove of DNA. A surface loop region, to which tumorigenic mutations map, has been identified as a functional surface important for Smad activity. This structure establishes a framework for understanding how Smad proteins may act in concert with other transcription factors in the regulation of TGF-β- responsive genes.
医学与生命科学
化合物
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 43.449 | 6.332 | |
2000 | 36.711 | 5.999 | |
2001 | 29.247 | 5.155 | |
2002 | 28.027 | 4.956 | |
2003 | 28.284 | 4.99 | |
2004 | 25.704 | 5.002 | |
2005 | 25.262 | 4.648 | |
2006 | 23.831 | 4.889 | |
2007 | 25.228 | 5.206 | |
2008 | 25.274 | 5.631 | |
2009 | 26.21 | 6.527 | |
2010 | 25.629 | 6.426 | |
2011 | 56.8 | 25.74 | 6.681 |
2012 | 55.5 | 25.117 | 6.9 |
2013 | 52.4 | 28.254 | 6.842 |
2014 | 53.9 | 28.505 | 6.776 |
2015 | 54.6 | 27.712 | 6.29 |
2016 | 53.5 | 27.691 | 6.043 |
2017 | 54.9 | 25.137 | 5.947 |
2018 | 56.2 | 25.976 | 6.769 |
2019 | 58.7 | 24.698 | 7.114 |
2020 | 62 | ||
2021 |
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