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Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes

作者：

Fatih Göğer , Gülmira Özek , Mehmet Tekin , Süleyman Yur , Temel Özek

作者单位：

摘要：

Methanol extract of Marrubium. sivasense Aytaç, Akgül & Ekici was analyzed with LC-MS/MS technique. Forsythoside B, verbascoside and leucoseptoside were identified as main compounds. Antioxidant properties of the extract was determined by DPPH free radical scavenging activity (IC50 0.34 mg/mL), trolox equivalent antioxidant capacity (TEAC) (2.3 mM±0.04), xanthine-xanthine oxidase(XO) inhibitory effect (16.54 %). and. B-carotene bleaching (Inh. 43±1.26 %) assays. The extract demonstrated hypoglycemic activity (Inh. 49.67±1.09 %.) via inhibition of porcine pancreatic α-amylase, the antiinflammatory effect of the extract tested via inhibition of 5-LOX was found as Inh 18.71±0.74 %, however no antityrosinase activity was found.

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DOI：

https://doi.org/10.18596/jotcsa.516888

来源期刊：

Journal of the Turkish Chemical Society, Section A: Chemistry

出版商：

Turkish Chemical Society

年，卷（期）：

2019;6(3):281-292