Yi Ren;Ronnie Tung Ping Poon;Hong Teng Tsui;Wen Hong Chen;Zhi Li;Cecilia Lau;Wun Ching Yu;上达 范
The University of Hong Kong
发表时间:2003-12-1
期 刊:Clinical Cancer Research
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0346103807&partnerID=8YFLogxK
Purpose: In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate its correlation with clinicopathological features and prognosis. Experimental Design: ELISA was used to detect the concentrations of IL-8, vascular endothelial growth factor, and macrophage migration inhibitory factor in preoperative sera of 59 patients with resection of HCC and 15 healthy subjects. Results: Preoperative serum IL-8 was found to be significantly elevated in patients with HCC compared with healthy subjects (median, 17.6 versus 1.0 pg/ml, P = 0.046). The levels of IL-8 correlated significantly with a large tumor size (>5 cm), absence of tumor capsule, presence of venous invasion, and advanced pathological tumor-node-metastasis stage. Serum IL-8 level was a significant prognostic factor in terms of disease-free and overall survival. Patients with a serum IL-8 level of >17.6 pg/ml had a poorer disease-free survival than those with a level of <17.6 pg/ml (median disease-free survival 4.7 versus 19.2 months). Multivariate analyses showed that serum IL-8 level was a significant and independent prognostic factor of survival. Conclusions: Significant correlations of serum IL-8 levels with tumor size and tumor stage suggest that IL-8 may be directly or indirectly involved in the progression of HCC. These findings indicate that serum IL-8 may be a useful biological marker of tumor invasiveness and an independent prognostic factor for patients with HCC.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 1.391 | 1.053 | |
2000 | 1.776 | 1.204 | |
2001 | 2.121 | 1.316 | |
2002 | 2.452 | 1.385 | |
2003 | 2.821 | 1.639 | |
2004 | 2.801 | 1.508 | |
2005 | 2.881 | 1.486 | |
2006 | 3.018 | 1.511 | |
2007 | 3.354 | 1.631 | |
2008 | 3.499 | 1.605 | |
2009 | 3.711 | 1.695 | |
2010 | 4.233 | 1.851 | |
2011 | 14.6 | 4.467 | 2.08 |
2012 | 15.3 | 4.712 | 2.102 |
2013 | 15.1 | 5.093 | 2.083 |
2014 | 15.8 | 4.947 | 2.083 |
2015 | 16.3 | 5.291 | 2.126 |
2016 | 16.2 | 4.846 | 2.002 |
2017 | 15.6 | 4.929 | 1.928 |
2018 | 16 | 4.965 | 1.893 |
2019 | 16.1 | 5.241 | 2.038 |
2020 | 19.1 | ||
2021 |
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