R. T.P. Poon;I. O.L. Ng;上达 范;E. C.S. Lai;C. M. Lo;C. L. Liu;J. Wong
The University of Hong Kong
发表时间:2001-6-15
期 刊:Journal of Clinical Oncology
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0035876047&partnerID=8YFLogxK
Purpose: This study aims to clarify the clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma (HCC). Patients and Methods: The clinicopathologic features of 5-year survivors and disease-free survivors were elucidated in a cohort of 230 patients prospectively observed for > 5 years (64 to 192 months) after curative resection of HCC. Results: The incidence of 5-year overall and disease-free survivors were 37% (85 of 230) and 20% (45 of 230), respectively. Clinicopathologic features associated with 5-year survivors included female sex (P = .024), preoperative serum albumin ≥ 40 g/L (P = .033), AST < 50 u/L (P = .001), tumor < 5 cm (P = .001), solitary tumor (P = .035), encapsulated tumor (P = .021), no venous invasion (P = .001), no microsatellite nodule (P = .001), and early pathologic tumor-node-metastasis (pTNM) stage (I or II, P < .001). Features favoring 5-year disease-free survivors were preoperative serum AST < 50 u/L (P = .007), tumor < 5 cm (P = .005), encapsulated tumor (P = .007), no venous invasion (P < .001), no microsatellite nodule (P = .001), and early pTNM stage (I or II, P < .001). By multivariate analysis, pTNM stage was the only significant predictive factor for both overall and disease-free survival. Conclusion: This study shows that long-term disease-free survival > 5 years after resection of HCC can be achieved in patients with favorable tumor characteristics. Early pTNM stage was the most reliable predictor of both long-term overall and disease-free survivors.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 3.066 | 3.656 | |
2000 | 3.972 | 3.914 | |
2001 | 4.111 | 3.97 | |
2002 | 4.274 | 3.801 | |
2003 | 5.044 | 4.28 | |
2004 | 5.274 | 3.993 | |
2005 | 5.261 | 4.074 | |
2006 | 5.478 | 3.641 | |
2007 | 6.889 | 4.005 | |
2008 | 7.238 | 3.943 | |
2009 | 7.574 | 4.199 | |
2010 | 8.326 | 4.289 | |
2011 | 26.7 | 9.128 | 4.793 |
2012 | 28.9 | 9.281 | 4.86 |
2013 | 27.8 | 8.389 | 4.649 |
2014 | 26.3 | 8.324 | 4.466 |
2015 | 28.6 | 9.146 | 4.914 |
2016 | 29.9 | 9.1 | 5.01 |
2017 | 31.4 | 10.683 | 5.221 |
2018 | 35.1 | 11.754 | 5.396 |
2019 | 35.4 | 10.054 | 5.568 |
2020 | 36.1 | ||
2021 |
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