Xiao Ni Kong;He Xin Yan;Lei Chen;Li Wei Dong;Wen Yang;Qiong Liu;Le Xing Yu;Dan Dan Huang;Shu Qin Liu;Hui Liu;孟超 吴;红阳 王
Second Military Medical University;China Association for Science and Technology
发表时间:2007-10-29
期 刊:Journal of Experimental Medicine
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=35748985290&partnerID=8YFLogxK
Activation of the mitogen-activated protein kinases (MAPKs) and nuclear factor κB (NF-κB) cascades after Toll-like receptor (TLR) stimulation contributes to innate immune responses. Signal regulatory protein (SIRP) α, a member of the SIRP family that is abundantly expressed in macrophages, has been implicated in regulating MAPK and NF-κB signaling pathways. In addition, SIRPα can negatively regulate the phagocytosis of host cells by macrophages, indicating an inhibitory role of SIRPα in innate immunity. We provide evidences that SIRPα is an essential endogenous regulator of the innate immune activation upon lipopolysaccharide (LPS) exposure. SIRPα expression was promptly reduced in macrophages after LPS stimulation. The decrease in SIRPα expression levels was required for initiation of LPS-induced innate immune responses because overexpression of SIRPα reduced macrophage responses to LPS. Knockdown of SIRPα caused prolonged activation of MAPKs and NF-κB pathways and augmented production of proinflammatory cytokines and type I interferon (IFN). Mice transferred with SIRPα-depleted macrophages were highly susceptible to endotoxic shock, developing multiple organ failure and exhibiting a remarkable increase in mortality. SIRPα may accomplish this mainly through its association and sequestration of the LPS signal transducer SHP-2. Thus, SIRPα functions as a biologically important modulator of TLR signaling and innate immunity. JEM
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | 12.049 | 2.799 | |
2000 | 11.026 | 2.764 | |
2001 | 10.608 | 2.736 | |
2002 | 10.994 | 2.734 | |
2003 | 10.93 | 2.79 | |
2004 | 11.07 | 2.723 | |
2005 | 11.025 | 2.66 | |
2006 | 11.948 | 2.78 | |
2007 | 13.089 | 2.907 | |
2008 | 13.704 | 2.888 | |
2009 | 12.581 | 2.801 | |
2010 | 13.544 | 2.881 | |
2011 | 26.5 | 13.066 | 2.886 |
2012 | 26.7 | 12.588 | 2.885 |
2013 | 25.9 | 12.387 | 2.949 |
2014 | 24.3 | 11.788 | 2.764 |
2015 | 24.3 | 10.719 | 2.611 |
2016 | 21.1 | 10.386 | 2.547 |
2017 | 18.2 | 8.615 | 2.274 |
2018 | 17.5 | 7.941 | 2.211 |
2019 | 18.2 | 7.757 | 2.221 |
2020 | 16.9 |
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