Wen Wen;Jin Ding;Wen Sun;Jing Fu;Yao Chen;Kun Wu;Beifang Ning;Tao Han;Lei Huang;Cheng Chen;东 谢;Zhong Li;Gensheng Feng;孟超 吴;渭芬 谢;红阳 王
International Cooperation Laboratory on Signal Transduction of Eastern Hepatobiliary Surgery Inst.;Second Military Medical University;CAS - Shanghai Institute for Biological Sciences;University of California at San Diego;Shanghai Jiao Tong University
发表时间:2012-6
期 刊:Hepatology
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=84861580616&partnerID=8YFLogxK
Cyclin G1 deficiency is associated with reduced incidence of carcinogen-induced hepatocellular carcinoma (HCC), but its function in HCC progression remains obscure. We report a critical role of cyclin G1 in HCC metastasis. Elevated expression of cyclin G1 was detected in HCCs (60.6%), and its expression levels were even higher in portal vein tumor thrombus. Clinicopathological analysis revealed a close correlation of cyclin G1 expression with distant metastasis and poor prognosis of HCC. Forced expression of cyclin G1 promoted epithelial-mesenchymal transition (EMT) and metastasis of HCC cells in vitro and in vivo. Cyclin G1 overexpression enhanced Akt activation through interaction with p85 (regulatory subunit of phosphoinositide 3-kinase [PI3K]), which led to subsequent phosphorylation of glycogen synthase kinase-3β (GSK-3β) and stabilization of Snail, a critical EMT mediator. These results suggest that elevated cyclin G1 facilitates HCC metastasis by promoting EMT via PI3K/Akt/GSK-3β/Snail-dependent pathway. Consistently, we have observed a significant correlation between cyclin G1 expression and p-Akt levels in a cohort of HCC patients, and found that combination of these two parameters is a more powerful predictor of poor prognosis. Conclusions: Cyclin G1 plays a pivotal role in HCC metastasis and may serve as a novel prognostic biomarker and therapeutic target.
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | 2.067 | 2.07 | |
2000 | 2.834 | 2.215 | |
2001 | 2.934 | 2.165 | |
2002 | 3.26 | 2.462 | |
2003 | 3.524 | 2.614 | |
2004 | 3.721 | 2.746 | |
2005 | 3.57 | 2.675 | |
2006 | 4.142 | 2.778 | |
2007 | 4.138 | 2.659 | |
2008 | 4.767 | 2.637 | |
2009 | 4.4 | 2.729 | |
2010 | 4.801 | 2.746 | |
2011 | 17.6 | 5.012 | 2.829 |
2012 | 18.5 | 5.2 | 2.861 |
2013 | 18.1 | 5.29 | 2.691 |
2014 | 17.3 | 5.155 | 2.606 |
2015 | 18 | 4.879 | 2.623 |
2016 | 19.9 | 5.229 | 2.756 |
2017 | 20.6 | 5.541 | 2.746 |
2018 | 20.7 | 5.096 | 2.856 |
2019 | 20.6 | 5.377 | 3.171 |
2020 | 21.9 | ||
2021 |
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