升平 李;Ji Qian;Yuan Yang;Wanting Zhao;Juncheng Dai;Jin Xin Bei;Jia Nee Foo;Paul J. McLaren;Zhiqiang Li;Jingmin Yang;Feng Shen;Li Liu;Jiamei Yang;Shuhong Li;Shandong Pan;Yi Wang;Wenjin Li;Xiangjun Zhai;Boping Zhou;Lehua Shi;Xinchun Chen;Minjie Chu;Yiqun Yan;Jun Wang;Shuqun Cheng;Jiawei Shen;Weihua Jia;Jibin Liu;Jiahe Yang;Zujia Wen;Aijun Li;Ying Zhang;Guoliang Zhang;Xianrong Luo;Hongbo Qin;Minshan Chen;Hua Wang;力 金;Dongxin Lin;洪兵 沈;Lin He;Paul I.W. de Bakker;红阳 王;益新 曾;孟超 吴;志斌 胡;咏勇 师;Jianjun Liu;Weiping Zhou
China Association for Science and Technology;Fudan University;Second Military Medical University;Agency for Science; Technology and Research;Nanjing Medical University;Sun Yat-Sen University;Harvard University;Shanghai Jiao Tong University;Nantong Tumor Hospital;Jiangsu Provincial Center for Disease Control and Prevention;The Third People's Municipal Hospital of Shenzhen;458th Hospital of the Chinese People's Liberation Army;Guangzhou First People's Hospital ;Chinese Academy of Medical Sciences;Chinese Academy of Sciences
发表时间:2012-7
期 刊:PLoS Genetics
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=84864621505&partnerID=8YFLogxK
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). To further identify novel susceptibility loci associated with HBV-related HCC and replicate the previously reported association, we performed a large three-stage GWAS in the Han Chinese population. 523,663 autosomal SNPs in 1,538 HBV-positive HCC patients and 1,465 chronic HBV carriers were genotyped for the discovery stage. Top candidate SNPs were genotyped in the initial validation samples of 2,112 HBV-positive HCC cases and 2,208 HBV carriers and then in the second validation samples of 1,021 cases and 1,491 HBV carriers. We discovered two novel associations at rs9272105 (HLA-DQA1/DRB1) on 6p21.32 (OR = 1.30, P = 1.13×10-19) and rs455804 (GRIK1) on 21q21.3 (OR = 0.84, P = 1.86×10-8), which were further replicated in the fourth independent sample of 1,298 cases and 1,026 controls (rs9272105: OR = 1.25, P = 1.71×10-4; rs455804: OR = 0.84, P = 6.92×10-3). We also revealed the associations of HLA-DRB1*0405 and 0901*0602, which could partially account for the association at rs9272105. The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC.
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | |||
2003 | |||
2004 | |||
2005 | |||
2006 | 3.979 | 1.531 | |
2007 | 4.875 | 1.831 | |
2008 | 5.063 | 1.764 | |
2009 | 5.762 | 1.907 | |
2010 | 8.111 | 1.881 | |
2011 | 12.6 | 7.415 | 1.909 |
2012 | 13.1 | 7.403 | 1.97 |
2013 | 11.9 | 7.107 | 1.815 |
2014 | 12.4 | 7.009 | 1.765 |
2015 | 12.1 | 6.39 | 1.625 |
2016 | 12.1 | 5.457 | 1.55 |
2017 | 11.1 | 4.829 | 1.406 |
2018 | 9.7 | 4.001 | 1.327 |
2019 | 9 | 3.744 | 1.368 |
2020 | 9 | 3.587 | 1.457 |
2021 | 7.3 |
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