鹏远 杨;Qi Jing Li;Yuxiong Feng;Yun Zhang;Geoffrey J. Markowitz;Shanglei Ning;Yuezhen Deng;Jiangsha Zhao;Shan Jiang;云飞 元;红阳 王;树群 程;东 谢;Xiao Fan Wang
Duke University;Second Military Medical University;CAS - Shanghai Institute for Biological Sciences;Sun Yat-Sen University
发表时间:2012-9-11
期 刊:Cancer Cell
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=84866018690&partnerID=8YFLogxK
Portal vein tumor thrombus (PVTT) is strongly correlated to a poor prognosis for patients with hepatocellular carcinoma (HCC). In this study, we uncovered a causative link between hepatitis B virus (HBV) infection and development of PVTT. Mechanistically, elevated TGF-β activity, associated with the persistent presence of HBV in the liver tissue, suppresses the expression of microRNA-34a, leading to enhanced production of chemokine CCL22, which recruits regulatory T (Treg) cells to facilitate immune escape. These findings strongly suggest that HBV infection and activity of the TGF-β-miR-34a-CCL22 axis serve as potent etiological factors to predispose HCC patients for the development of PVTT, possibly through the creation of an immune-subversive microenvironment to favor colonization of disseminated HCC cells in the portal venous system.
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | |||
2003 | 9.46 | 2.447 | |
2004 | 11.168 | 2.773 | |
2005 | 11.785 | 2.73 | |
2006 | 12.358 | 3.274 | |
2007 | 12.992 | 3.742 | |
2008 | 15.652 | 4.394 | |
2009 | 15.159 | 4.58 | |
2010 | 16.468 | 4.656 | |
2011 | 40 | 16.203 | 4.757 |
2012 | 42.4 | 16.267 | 4.927 |
2013 | 43.9 | 17.638 | 4.971 |
2014 | 40.4 | 14.883 | 4.609 |
2015 | 41.7 | 13.74 | 4.94 |
2016 | 40.3 | 13.509 | 5.1 |
2017 | 44.3 | 12.7 | 4.896 |
2018 | 37.8 | 11.741 | 4.702 |
2019 | 40.7 | 11.909 | 5.033 |
2020 | 40.2 | 13.035 | 5.764 |
2021 | 33.5 |
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