Ling Hao Zhao;Xiao Liu;He Xin Yan;Wei Yang Li;Xi Zeng;Yuan Yang;Jie Zhao;Shi Ping Liu;Xue Han Zhuang;Chuan Lin;Chen Jie Qin;Yi Zhao;Ze Ya Pan;Gang Huang;Hui Liu;Jin Zhang;Ruo Yu Wang;Yun Yang;Wen Wen;Gui Shuai Lv;Hui Lu Zhang;Han Wu;Shuai Huang;Ming Da Wang;Liang Tang;Hong Zhi Cao;Ling Wang;T. P. Lee;Hui Jiang;冶雄 谈;Sheng Xian Yuan;Guo Jun Hou;Qi Fei Tao;Qin Guo Xu;Xiu Qing Zhang;孟超 吴;Xun Xu;军 王;焕明 杨;Wei Ping Zhou;红阳 王
Second Military Medical University;National Center for Liver Cancer;BGI-Shenzhen;South China University of Technology;Chinese University of Hong Kong;Fourth Military Medical University;University of Copenhagen;Shanghai Jiao Tong University
发表时间:2016-10-5
期 刊:Nature Communications
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=84990922469&partnerID=8YFLogxK
Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We show that HBV is prone to integrate into rare fragile sites and functional genomic regions including CpG islands. We observe a distinct pattern in the preferential sites of HBV integration between tumour and non-tumour tissues. HBV insertional sites are significantly enriched in the proximity of telomeres in tumours. Recurrent HBV target genes are identified with few that overlap. The overall HBV integration frequency is much higher in tumour genomes of males than in females, with a significant enrichment of integration into chromosome 17. Furthermore, a cirrhosis-dependent HBV integration pattern is observed, affecting distinct targeted genes. Our data suggest that HBV integration has a high potential to drive oncogenic transformation.
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2011 | 2.5 | 3.137 | 2.66 |
2012 | 6.5 | 5.866 | 3.267 |
2013 | 9.4 | 6.206 | 2.988 |
2014 | 10.9 | 6.41 | 3.102 |
2015 | 13.3 | 6.287 | 2.877 |
2016 | 16.9 | 6.414 | 2.916 |
2017 | 18.5 | 6.582 | 2.967 |
2018 | 18.1 | 5.992 | 2.883 |
2019 | 18.1 | 5.569 | 2.847 |
2020 | 20 | 5.559 | 3.055 |
2021 | 18.5 |
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