Minghong Jiang;Shikun Zhang;Zongheng Yang;Hongyu Lin;Jun Zhu;Lun Liu;Wendie Wang;Shuo Liu;Wei Liu;Yuanwu Ma;Lianfeng Zhang;雪涛 曹
Chinese Academy of Medical Sciences;Institute of Laboratory Animal Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College;Second Military Medical University;Nankai University
发表时间:2018-5-3
期 刊:Cell
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=85046126215&partnerID=8YFLogxK
The innate RNA sensor RIG-I is critical in the initiation of antiviral type I interferons (IFNs) production upon recognition of “non-self” viral RNAs. Here, we identify a host-derived, IFN-inducible long noncoding RNA, lnc-Lsm3b, that can compete with viral RNAs in the binding of RIG-I monomers and feedback inactivate the RIG-I innate function at late stage of innate response. Mechanistically, binding of lnc-Lsm3b restricts RIG-I protein's conformational shift and prevents downstream signaling, thereby terminating type I IFNs production. Multivalent structural motifs and long-stem structure are critical features of lnc-Lsm3b for RIG-I binding and inhibition. These data reveal a non-canonical self-recognition mode in the regulation of immune response and demonstrate an important role of an inducible “self” lncRNA acting as a potent molecular decoy actively saturating RIG-I binding sites to restrict the duration of “non-self” RNA-induced innate immune response and maintaining immune homeostasis, with potential utility in inflammatory disease management. A self-recognition mode between RIG-I and an inducible host lncRNA functions to restrict innate immune response in a feedback manner.
化合物
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 43.449 | 6.323 | |
2000 | 36.711 | 5.999 | |
2001 | 29.247 | 5.146 | |
2002 | 28.027 | 4.956 | |
2003 | 28.284 | 4.99 | |
2004 | 25.704 | 4.859 | |
2005 | 25.262 | 4.518 | |
2006 | 23.831 | 4.746 | |
2007 | 25.228 | 5.201 | |
2008 | 25.274 | 5.623 | |
2009 | 26.21 | 6.663 | |
2010 | 25.629 | 6.451 | |
2011 | 56.8 | 25.74 | 6.79 |
2012 | 55.5 | 25.117 | 6.923 |
2013 | 52.4 | 28.254 | 6.891 |
2014 | 53.9 | 28.505 | 6.758 |
2015 | 54.6 | 27.712 | 6.314 |
2016 | 53.5 | 27.691 | 6.047 |
2017 | 54.9 | 25.137 | 5.982 |
2018 | 56.2 | 25.976 | 6.825 |
2019 | 58.7 | 24.698 | 7.137 |
2020 | 63.4 | 26.304 | 8.154 |
2021 | 61.3 |
相似文献推荐