Jin Hou;Li Lin;Weiping Zhou;Zhengxin Wang;Guoshan Ding;Qiongzhu Dong;伦秀 钦;Xiaobing Wu;Yuanyuan Zheng;Yun Yang;Wei Tian;Qian Zhang;Chunmei Wang;Qinghua Zhang;Shi Mei Zhuang;利民 郑;Anmin Liang;Wenzhao Tao;雪涛 曹
Second Military Medical University;Tsinghua University;Zhejiang University;Hospital of Hepatobiliary Surgery;Fudan University;China CDC;CAS - Beijing Institute of Genomics;Sun Yat-Sen University;Guangxi Medical University
发表时间:2011-2-15
期 刊:Cancer Cell
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=79751484450&partnerID=8YFLogxK
The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and hepatocellular carcinoma (HCC) was carried out in this study. We found nine miRNAs accounted for ∼88.2% of the miRNome in human liver. The third most highly expressed miR-199a/b-3p is consistently decreased in HCC, and its decrement significantly correlates with poor survival of HCC patients. Moreover, miR-199a/b-3p can target tumor-promoting PAK4 to suppress HCC growth through inhibiting PAK4/Raf/MEK/ERK pathway both in vitro and in vivo. Our study provides miRNomes of human liver and HCC and contributes to better understanding of the important deregulated miRNAs in HCC and liver diseases.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | |||
2003 | 9.46 | 2.445 | |
2004 | 11.168 | 2.781 | |
2005 | 11.785 | 2.723 | |
2006 | 12.358 | 3.276 | |
2007 | 12.992 | 3.742 | |
2008 | 15.652 | 4.408 | |
2009 | 15.159 | 4.558 | |
2010 | 16.468 | 4.669 | |
2011 | 40 | 16.203 | 4.749 |
2012 | 42.4 | 16.267 | 4.92 |
2013 | 43.9 | 17.638 | 4.933 |
2014 | 40.4 | 14.883 | 4.632 |
2015 | 41.7 | 13.74 | 4.934 |
2016 | 40.3 | 13.509 | 5.089 |
2017 | 44.3 | 12.7 | 4.877 |
2018 | 37.8 | 11.741 | 4.691 |
2019 | 40.7 | 11.909 | 5.086 |
2020 | 39.1 |
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