楠 李;Weiping Zhang;涛 万;Jia Zhang;Taoyong Chen;Yizhi Yu;Jianli Wang;雪涛 曹
China Association for Science and Technology;Second Military Medical University;Zhejiang University
发表时间:2001-7-27
期 刊:Journal of Biological Chemistry
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0035958861&partnerID=8YFLogxK
The Siglecs (sialic acid-binding Ig-like lectins) are a subfamily of I-type lectins, which specifically recognize sialic acids. Nine members of the family have been identified thus far. We have obtained a novel cDNA clone from a human dendritic cell cDNA library encoding a protein with sequence and structural features of the Siglec family, hence designated as Siglec-10. The full-length Siglec-10 cDNA encodes a type 1 transmembrane protein containing four extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail with two classical immunoreceptor tyrosine-based inhibitory motifs. The N-terminal V-set Ig domain has most of the amino acid residues typical of the Siglecs. Siglec-10 shows the closest homology to Siglec-5 and Siglec-3/CD33. Various cells and cell lines including monocytes and dendritic cells express Siglec-10. High levels of mRNA expression were seen in peripheral blood leukocytes, spleen, and liver. When expressed on COS-7 cells, Siglec-10 was able to bind human red blood cells and soluble sialoglycoconjugates in a sialic acid-dependent manner. The identification of Siglec-10 as a new Siglec family member and its expression profile, together with its sialic acid-dependent binding capacity, suggest that it may be involved in cell-cell recognition by interacting with sialylated ligands expressed on specific cell populations.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 6.161 | 1.611 | |
2000 | 5.435 | 1.559 | |
2001 | 4.869 | 1.505 | |
2002 | 4.494 | 1.42 | |
2003 | 4.512 | 1.416 | |
2004 | 4.376 | 1.42 | |
2005 | 4.178 | 1.351 | |
2006 | 4.352 | 1.379 | |
2007 | 4.338 | 1.379 | |
2008 | 4.375 | 1.362 | |
2009 | 4.235 | 1.348 | |
2010 | 3.998 | 1.341 | |
2011 | 8.3 | 3.544 | 1.253 |
2012 | 8.3 | 3.396 | 1.235 |
2013 | 8.9 | 3.402 | 1.218 |
2014 | 8.8 | 3.258 | 1.206 |
2015 | 8.8 | 3.126 | 1.18 |
2016 | 8.5 | 2.825 | 1.129 |
2017 | 8.2 | 2.672 | 1.096 |
2018 | 7.7 | 2.403 | 1.089 |
2019 | 7.4 | 2.283 | 1.089 |
2020 | 7.6 | ||
2021 |
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