Feng Liu;Jiong Lu;Wei Hu;Sheng Yue Wang;Shu Jian Cui;Ming Chi;Qing Yan;Xin Rong Wang;怀东 宋;Xue Nian Xu;Ju Jun Wang;Xiang Lin Zhang;Xin Zhang;Zhi Qin Wang;Chun Liang Xue;Paul J. Brindley;Donald P. McManus;Peng Yuan Yang;Zheng Feng;竺 陈;Ze Guang Han
Chinese National Human Genome Center;Fudan University;Chinese Center for Disease Control and Prevention;Shanghai Jiao Tong University;Tulane University;Queensland Institute of Medical Research
发表时间:2006-4
期 刊:PLoS Pathogens
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=33646262570&partnerID=8YFLogxK
Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries. Here we isolated ∼8,400 potential protein-encoding cDNA contigs from Schistosoma japonicum after sequencing circa 84,000 expressed sequence tags. In tandem, we undertook a high-throughput proteomics approach to characterize the protein expression profiles of a number of developmental stages (cercariae, hepatic schistosomula, female and male adults, eggs, and miracidia) and tissues at the host-parasite interface (eggshell and tegument) by interrogating the protein database deduced from the contigs. Comparative analysis of these transcriptomic and proteomic data, the latter including 3,260 proteins with putative identities, revealed differential expression of genes among the various developmental stages and sexes of S. japonicum and localization of putative secretory and membrane antigens, enzymes, and other gene products on the adult tegument and eggshell, many of which displayed genetic polymorphisms. Numerous S. japonicum genes exhibited high levels of identity with those of their mammalian hosts, whereas many others appeared to be conserved only across the genus Schistosoma or Phylum Platyhelminthes. These findings are expected to provide new insights into the pathophysiology of schistosomiasis and for the development of improved interventions for disease control and will facilitate a more fundamental understanding of schistosome biology, evolution, and the host-parasite interplay.
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | |||
2003 | |||
2004 | |||
2005 | |||
2006 | 3.145 | 1.375 | |
2007 | 4.18 | 1.939 | |
2008 | 3.771 | 1.812 | |
2009 | 3.912 | 1.878 | |
2010 | 4.859 | 1.911 | |
2011 | 12.3 | 5.736 | 2.019 |
2012 | 13.7 | 5.051 | 1.951 |
2013 | 13.3 | 5.511 | 2.023 |
2014 | 12.9 | 5.324 | 1.928 |
2015 | 12.9 | 5.144 | 1.793 |
2016 | 12.5 | 4.736 | 1.689 |
2017 | 11.5 | 4.006 | 1.583 |
2018 | 11.1 | 3.909 | 1.552 |
2019 | 11 | 3.64 | 1.569 |
2020 | 10.9 | ||
2021 |
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