Xun Chu;Chun Ming Pan;Shuang Xia Zhao;Jun Liang;Guan Qi Gao;Xiao Mei Zhang;Guo Yue Yuan;Chang Gui Li;Li Qiong Xue;Min Shen;Wei Liu;Fang Xie;Shao Ying Yang;Hai Feng Wang;Jing Yi Shi;Wei Wei Sun;Wen Hua Du;Chun Lin Zuo;Jin Xiu Shi;Bing Li Liu;Cui Cui Guo;Ming Zhan;Zhao Hui Gu;Xiao Na Zhang;Fei Sun;Zhi Quan Wang;Zhi Yi Song;Cai Yan Zou;Wei Hua Sun;Ting Guo;Huang Ming Cao;Jun Hua Ma;Bing Han;Ping Li;He Jiang;Qiu Hua Huang;Liming Liang;Li Bin Liu;Gang Chen;Qing Su;Yong De Peng;Jia Jun Zhao;Guang Ning;Zhu Chen;Jia Lun Chen;Sai Juan Chen;Wei Huang;Huai Dong Song
Shanghai Jiao Tong University;Key Laboratory of Health and Disease Genomics;Xuzhou Central Hospital;Linyi People's Hospital;Bengbu Medical College;Jiangsu University;Qingdao University;Harvard University;Fujian Medical University;Fujian Provincial Hospital;Shandong University
发表时间:2011-9
期 刊:Nature Genetics
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=80052260527&partnerID=8YFLogxK
Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P combined = 6.85 ×10-10 for rs9355610) and an intergenic region at 4p14 (P combined = 1.08 ×10-13 for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 14.31 | 5.209 | |
2000 | 14.412 | 5.509 | |
2001 | 15.204 | 5.69 | |
2002 | 13.168 | 5.248 | |
2003 | 13.523 | 4.987 | |
2004 | 13.814 | 5.295 | |
2005 | 14.345 | 5.197 | |
2006 | 14.302 | 4.991 | |
2007 | 17.931 | 4.885 | |
2008 | 20.87 | 5.156 | |
2009 | 24.768 | 6.337 | |
2010 | 28.013 | 6.67 | |
2011 | 60.4 | 25.298 | 7.246 |
2012 | 57.2 | 25.621 | 7.106 |
2013 | 50.9 | 24.193 | 6.251 |
2014 | 48.9 | 23.98 | 6.24 |
2015 | 50.1 | 24.157 | 6.669 |
2016 | 52.3 | 21.979 | 6.805 |
2017 | 45.4 | 22.243 | 6.006 |
2018 | 45.1 | 21.508 | 5.673 |
2019 | 45.2 | 19.795 | 5.994 |
2020 | 50.5 | 18.861 | 6.722 |
2021 | 46 |
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