Changjin Huang;Yao Zhang;Hongyan Yuan;华健 高;Sulin Zhang
Pennsylvania State University;Brown University;Harvard University
发表时间:2013-9-11
期 刊:Nano Letters
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=84884252848&partnerID=8YFLogxK
Nanoparticles (NPs) hold great promises for targeted disease diagnosis and therapy. Despite considerable progress in biomimetic design of NP-bioconjugates, the roles of NP size and shape in endocytosis are still not fully understood. Using an efficient coarse-grained molecular dynamics (CGMD) model, we simulate receptor-mediated endocytosis of NPs of various sizes and shapes. Our simulations demonstrate that both NP size and shape modulate the kinetics of endocytosis. For spherical NPs, there exists an optimal size at which endocytosis takes the shortest time. For a spherocylindrical NP with the initial upright docking position on the membrane plane, endocytosis proceeds through a laying-down-then-standing-up sequence. A free energy analysis reveals that NP size primarily determines whether endocytosis can complete, while NP shape breaks the symmetry of curvature energy landscape and hence dictates the endocytic pathway and the angle of entry. The findings shed light on the rational design of NP-based diagnostic and therapeutic agents with improved cellular targeting.
化合物
工程与材料科学
物理与天文学
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | 2.42 | 1.713 | |
2003 | 3.527 | 2.092 | |
2004 | 5.347 | 2.321 | |
2005 | 6.833 | 2.84 | |
2006 | 7.653 | 3.188 | |
2007 | 6.963 | 2.914 | |
2008 | 7.649 | 2.931 | |
2009 | 7.852 | 2.87 | |
2010 | 9.38 | 3.251 | |
2011 | 20.1 | 9.832 | 3.677 |
2012 | 21.3 | 10.269 | 3.523 |
2013 | 22.6 | 9.081 | 3.356 |
2014 | 22.5 | 8.268 | 3.413 |
2015 | 22.9 | 8.359 | 3.071 |
2016 | 22.4 | 7.893 | 2.694 |
2017 | 22.4 | 7.447 | 2.537 |
2018 | 21.2 | 6.211 | 2.427 |
2019 | 20.5 | 5.786 | 2.271 |
2020 | 19 | ||
2021 |
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