Lifetime and strength of adhesive molecular bond clusters between elastic media

Jin Qian;记增 王;华健 高

Brown University

发表时间:2008-2-19

期 刊:Langmuir

语 言:English

U R L: http://www.scopus.com/inward/record.url?scp=40449122315&partnerID=8YFLogxK

摘要

With a long-term objective toward a quantitative understanding of cell adhesion, we consider an idealized theoretical model of a cluster of molecular bonds between two dissimilar elastic media subjected to an applied tensile load. In this model, the distribution of interfacial traction is assumed to obey classical elastic equations whereas the rupture and rebinding of individual molecular bonds are governed by stochastic equations. Monte Carlo simulations that combine the elastic and stochastic equations are conducted to investigate the lifetime of the bond cluster as a function of the applied load. We show that the interfacial traction is generally nonuniform and for a given adhesion size the average cluster lifetime asymptotically approaches infinity as the applied load is reduced to below a critical value, defined as the strength of the cluster. The effects of elastic moduli, adhesion size, and rebinding rate on the cluster lifetime and strength are studied under strongly nonuniform distributions of interfacial traction. Although overly simplified in a number of aspects, our model seems to give predictions that are consistent with relevant experimental observations on focal adhesion dynamics.

相关科学

化学
电化学
光谱学
材料科学
物理学和天文学
凝聚态物理学
表面与界面

被引量

期刊度量

Scopus度量

年份 CiteScore SJR SNIP
1996
1997
1998
1999 1.638 1.447
2000 1.984 1.438
2001 2.038 1.333
2002 2.035 1.449
2003 2.013 1.398
2004 1.979 1.446
2005 2.19 1.449
2006 2.392 1.413
2007 2.473 1.411
2008 2.389 1.307
2009 2.164 1.333
2010 2.158 1.384
2011 7 2.051 1.341
2012 7.4 2.179 1.359
2013 8 1.896 1.331
2014 7.8 1.81 1.363
2015 7.9 1.65 1.276
2016 7.3 1.559 1.169
2017 6.9 1.479 1.136
2018 6.2 1.209 1.047
2019 6.1 1.088 1.022
2020 6.1
2021

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