Jinmin Ma;Fang Zhao;Wei Su;Qiongfang Li;Jiandong Li;Jingkai Ji;Yong Deng;Yang Zhou;Xinfa Wang;焕明 杨;Nitin K. Saksena;Karsten Kristiansen;Hui Wang;Yingxia Liu
University of Copenhagen;China National GeneBank;Shenzhen Third People's Hospital;BGI-Shenzhen;China Association for Science and Technology;IGO;University of Oxford
发表时间:2018
期 刊:Personalized Medicine
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=85050766132&partnerID=8YFLogxK
Aim: Co-infection in HIV-1 patients with Mycobacterium tuberculosis poses considerable risk of developing the immune reconstitution inflammatory syndrome (IRIS), especially upon the initiation of antiretroviral therapy (ART). Methodology & results: For transcriptomic analysis, peripheral blood mononuclear cells' whole gene expression was used from three patient groups: HIV + (H), HIV-TB + (HT), HIV-TB + with IRIS (HTI). Pathway enrichment and functional analysis was performed before and after highly active ART. Genes in the interferon-stimulating and ZNF families maintained tight functional interaction and tilted the balance in favor of TB-IRIS. Discussion & conclusion: The functional impairment of interaction between ZNF genes and interferon-stimulated genes, along with higher expression of S100A8/S100A9 genes possibly forms the genomic basis of TB-IRIS in a subset of HIV patients while on highly active ART.
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年份 | CiteScore | SJR | SNIP |
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1997 | |||
1998 | |||
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2000 | |||
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2002 | |||
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2004 | |||
2005 | |||
2006 | |||
2007 | 0.209 | 0.309 | |
2008 | 0.252 | 0.5 | |
2009 | 0.222 | 0.122 | |
2010 | 0.215 | 0.253 | |
2011 | 1.6 | 0.337 | 0.238 |
2012 | 1.7 | 0.339 | 0.441 |
2013 | 1.8 | 0.392 | 0.418 |
2014 | 2 | 0.389 | 0.504 |
2015 | 1.9 | 0.325 | 0.248 |
2016 | 2.1 | 0.464 | 0.334 |
2017 | 1.7 | 0.348 | 0.257 |
2018 | 1.5 | 0.312 | 0.256 |
2019 | 2.1 | 0.486 | 0.445 |
2020 | 2.5 |
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