Neil D. Young;Aaron R. Jex;Bo Li;Shiping Liu;Linfeng Yang;Zijun Xiong;Yingrui Li;Cinzia Cantacessi;Ross S. Hall;Xun Xu;Fangyuan Chen;Xuan Wu;Adhemar Zerlotini;Guilherme Oliveira;Andreas Hofmann;Guojie Zhang;Xiaodong Fang;Yi Kang;Bronwyn E. Campbell;Alex Loukas;Shoba Ranganathan;David Rollinson;Gabriel Rinaldi;Paul J. Brindley;焕明 杨;军 王;Jian Wang;Robin B. Gasser
University of Melbourne;CAS - Beijing Institute of Genomics;Fundação Oswaldo Cruz;Griffith University Queensland;James Cook University Queensland;Macquarie University;National University of Singapore;The Natural History Museum; London;Universidad de la República;George Washington University
发表时间：2012-2
期 刊：Nature Genetics
语 言：English
U R L： http://www.scopus.com/inward/record.url?scp=84862777661&partnerID=8YFLogxK
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.
医学与生命科学
Scopus度量
| 年份 | CiteScore | SJR | SNIP |
|---|---|---|---|
| 1996 | |||
| 1997 | |||
| 1998 | |||
| 1999 | 14.31 | 5.209 | |
| 2000 | 14.412 | 5.509 | |
| 2001 | 15.204 | 5.69 | |
| 2002 | 13.168 | 5.248 | |
| 2003 | 13.523 | 4.987 | |
| 2004 | 13.814 | 5.292 | |
| 2005 | 14.345 | 5.183 | |
| 2006 | 14.302 | 4.991 | |
| 2007 | 17.931 | 4.885 | |
| 2008 | 20.87 | 5.153 | |
| 2009 | 24.768 | 6.295 | |
| 2010 | 28.013 | 6.717 | |
| 2011 | 60.4 | 25.298 | 7.218 |
| 2012 | 57.2 | 25.621 | 7.088 |
| 2013 | 50.9 | 24.193 | 6.227 |
| 2014 | 48.9 | 23.98 | 6.262 |
| 2015 | 50.1 | 24.157 | 6.62 |
| 2016 | 52.3 | 21.979 | 6.79 |
| 2017 | 45.4 | 22.243 | 5.98 |
| 2018 | 45.1 | 21.508 | 5.648 |
| 2019 | 45.2 | 19.795 | 6.001 |
| 2020 | 49.3 | ||
| 2021 |
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