Guangwu Guo;Yaoting Gui;Shengjie Gao;Aifa Tang;Xueda Hu;Yi Huang;Wenlong Jia;Zesong Li;Minghui He;Liang Sun;Pengfei Song;Xiaojuan Sun;Xiaokun Zhao;Sangming Yang;Chaozhao Liang;Shengqing Wan;芳坚 周;Chao Chen;Jialou Zhu;Xianxin Li;Minghan Jian;Liang Zhou;Rui Ye;Peide Huang;Jing Chen;Tao Jiang;Xiao Liu;Yong Wang;Jing Zou;Zhimao Jiang;Renhua Wu;Song Wu;Fan Fan;Zhongfu Zhang;Lin Liu;Ruilin Yang;Xingwang Liu;Haibo Wu;Weihua Yin;Xia Zhao;Yuchen Liu;Huanhuan Peng;秉华 江;Qingxin Feng;Cailing Li;Jun Xie;Jingxiao Lu;Karsten Kristiansen;Yingrui Li;Xiuqing Zhang;Songgang Li;Jian Wang;焕明 杨;Zhiming Cai;军 王
Shenzhen Key Laboratory of Transomics Biotechnologies;Hong Kong University of Science and Technology;Shenzhen University;Central South University;Anhui Medical University;China Association for Science and Technology;Wuhan University;University of Copenhagen
发表时间：2012-1
期 刊：Nature Genetics
语 言：English
U R L： http://www.scopus.com/inward/record.url?scp=84655176646&partnerID=8YFLogxK
We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of ∼1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of HIF1α and HIF2α in the tumors (P = 0.01 and 0.04, respectively). Our findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network.
Scopus度量
| 年份 | CiteScore | SJR | SNIP |
|---|---|---|---|
| 1996 | |||
| 1997 | |||
| 1998 | |||
| 1999 | 14.31 | 5.209 | |
| 2000 | 14.412 | 5.509 | |
| 2001 | 15.204 | 5.69 | |
| 2002 | 13.168 | 5.248 | |
| 2003 | 13.523 | 4.987 | |
| 2004 | 13.814 | 5.292 | |
| 2005 | 14.345 | 5.183 | |
| 2006 | 14.302 | 4.991 | |
| 2007 | 17.931 | 4.885 | |
| 2008 | 20.87 | 5.153 | |
| 2009 | 24.768 | 6.295 | |
| 2010 | 28.013 | 6.717 | |
| 2011 | 60.4 | 25.298 | 7.218 |
| 2012 | 57.2 | 25.621 | 7.088 |
| 2013 | 50.9 | 24.193 | 6.227 |
| 2014 | 48.9 | 23.98 | 6.262 |
| 2015 | 50.1 | 24.157 | 6.62 |
| 2016 | 52.3 | 21.979 | 6.79 |
| 2017 | 45.4 | 22.243 | 5.98 |
| 2018 | 45.1 | 21.508 | 5.648 |
| 2019 | 45.2 | 19.795 | 6.001 |
| 2020 | 47.9 |
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