Joshua P. Frederick;Nicole T. Liberati;David S. Waddell;一公 施;Xiao Fan Wang
Duke University;Massachusetts General Hospital;China Association for Science and Technology
发表时间:2004-3
期 刊:Molecular and Cellular Biology
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=1542314236&partnerID=8YFLogxK
Smad proteins are the most well-characterized intracellular effectors of the transforming growth factor β (TGF-β) signal. The ability of the Smads to act as transcriptional activators via TGF-β-induced recruitment to Smad binding elements (SBE) within the promoters of TGF-β target genes has been firmly established. However, the elucidation of the molecular mechanisms involved in TGF-β-mediated transcriptional repression are only recently being uncovered. The proto-oncogene c-myc is repressed by TGF-β, and this repression is required for the manifestation of the TGF-β cytostatic program in specific cell types. We have shown that Smad3 is required for both TGF-β-induced repression of c-myc and subsequent growth arrest in keratinocytes. The transcriptional repression of c-myc is dependent on direct Smad3 binding to a novel Smad binding site, termed a repressive Smad binding element (RSBE), within the TGF-β inhibitory element (TIE) of the c-myc promoter. The c-myc TIE is a composite element, comprised of an overlapping RSBE and a consensus E2F site, that is capable of binding at least Smad3, Smad4, E2F-4, and p107. The RSBE is distinct from the previously defined SBE and may partially dictate, in conjunction with the promoter context of the overlapping E2F site, whether the Smad3-containing complex actively represses, as opposed to transactivates, the c-myc promoter.
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 10.319 | 1.691 | |
2000 | 9.042 | 1.658 | |
2001 | 8.631 | 1.629 | |
2002 | 8.05 | 1.523 | |
2003 | 7.71 | 1.506 | |
2004 | 7.266 | 1.509 | |
2005 | 6.776 | 1.399 | |
2006 | 6.657 | 1.4 | |
2007 | 6.675 | 1.372 | |
2008 | 6.328 | 1.343 | |
2009 | 6.304 | 1.392 | |
2010 | 6.029 | 1.393 | |
2011 | 11.7 | 5.427 | 1.34 |
2012 | 10.8 | 4.809 | 1.323 |
2013 | 9.9 | 4.546 | 1.187 |
2014 | 9.3 | 4.227 | 1.155 |
2015 | 8.8 | 3.831 | 1.115 |
2016 | 8.9 | 3.478 | 1.11 |
2017 | 8.4 | 3.174 | 0.972 |
2018 | 7.6 | 2.603 | 0.95 |
2019 | 7.3 | 2.298 | 0.974 |
2020 | 6.4 |
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