Shenjie Wu;Wenqi Song;Catherine C.L. Wong;一公 施
Tsinghua University;Peking University;China Association for Science and Technology
发表时间:2019-1-2
期 刊:Proceedings of the National Academy of Sciences of the United States of America
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=85059466441&partnerID=8YFLogxK
Presenilin is the catalytic subunit of γ-secretase, a four-component intramembrane protease responsible for the generation of β-amyloid (Aβ) peptides. Over 200 Alzheimer’s disease-related mutations have been identified in presenilin 1 (PS1) and PS2. Here, we report that Bax-inhibitor 1 (BI1), an evolutionarily conserved transmembrane protein, stably associates with PS1. BI1 specifically interacts with PS1 in isolation, but not with PS1 in the context of an assembled γ-secretase. The PS1–BI1 complex exhibits no apparent proteolytic activity, as judged by the inability to produce Aβ40 and Aβ42 from the substrate APP-C99. At an equimolar concentration, BI1 has no impact on the proteolytic activity of γ-secretase; at a 200-fold molar excess, BI1 reduces γ-secretase activity nearly by half. Our biochemical study identified BI1 as a PS1-interacting protein, suggesting additional functions of PS1 beyond its involvement in γ-secretase.
医学与生命科学
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 8.52 | 2.398 | |
2000 | 7.927 | 2.452 | |
2001 | 7.189 | 2.458 | |
2002 | 7.281 | 2.498 | |
2003 | 7.129 | 2.507 | |
2004 | 7.197 | 2.617 | |
2005 | 6.94 | 2.546 | |
2006 | 6.849 | 2.45 | |
2007 | 6.867 | 2.46 | |
2008 | 7.034 | 2.431 | |
2009 | 7.025 | 2.552 | |
2010 | 6.898 | 2.541 | |
2011 | 16.8 | 6.864 | 2.632 |
2012 | 17.3 | 6.868 | 2.679 |
2013 | 17.4 | 7.073 | 2.721 |
2014 | 17.2 | 6.898 | 2.706 |
2015 | 17.8 | 6.814 | 2.664 |
2016 | 18 | 6.576 | 2.648 |
2017 | 17.1 | 6.092 | 2.655 |
2018 | 16.1 | 5.601 | 2.598 |
2019 | 15.7 | 5.165 | 2.689 |
2020 | 14.3 |
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