Svetlana A. Fayngerts;Jianping Wu;Camilla L. Oxley;Xianglan Liu;Anastassios Vourekas;Terry Cathopoulis;Zhaojun Wang;Jian Cui;Suxia Liu;Honghong Sun;Mark A. Lemmon;Lining Zhang;一公 施;有海 陈
University of Pennsylvania;Tsinghua University;Shandong University
发表时间:2014-10-13
期 刊:Cancer Cell
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=84907984155&partnerID=8YFLogxK
More than half of human cancers have aberrantly upregulated phosphoinositide signals; yet how phospholipid signals are controlled during tumorigenesis is not fully understood. We report here that TIPE3 (TNFAIP8L3) is the transfer protein of phosphoinositide second messengers that promote cancer. High-resolution crystal structure of TIPE3 shows a large hydrophobic cavity that is occupied by a phospholipid-like molecule. TIPE3 preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5-bisphosphateand phosphatidylinositol 3,4,5-trisphosphate, and increases their levels in the plasma membrane. Notably, human cancers have markedly upregulated TIPE3 expression. Knocking out TIPE3 diminishes tumorigenesis, whereas enforced TIPE3 expression enhances it invivo. Thus, the function and metabolism of phosphoinositide second messengers are controlled by a specific transfer protein during tumorigenesis.
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | |||
2000 | |||
2001 | |||
2002 | |||
2003 | 9.46 | 2.445 | |
2004 | 11.168 | 2.781 | |
2005 | 11.785 | 2.723 | |
2006 | 12.358 | 3.276 | |
2007 | 12.992 | 3.742 | |
2008 | 15.652 | 4.408 | |
2009 | 15.159 | 4.558 | |
2010 | 16.468 | 4.669 | |
2011 | 40 | 16.203 | 4.749 |
2012 | 42.4 | 16.267 | 4.92 |
2013 | 43.9 | 17.638 | 4.933 |
2014 | 40.4 | 14.883 | 4.632 |
2015 | 41.7 | 13.74 | 4.934 |
2016 | 40.3 | 13.509 | 5.089 |
2017 | 44.3 | 12.7 | 4.877 |
2018 | 37.8 | 11.741 | 4.691 |
2019 | 40.7 | 11.909 | 5.086 |
2020 | 39.5 | ||
2021 |
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