Jia Wei Wu;Ariel R. Krawitz;继杰 柴;Wenyu Li;Fangjiu Zhang;Kunxin Luo;一公 施
Princeton University;University of California at Berkeley
发表时间:2002-11-1
期 刊:Cell
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0036848069&partnerID=8YFLogxK
The Ski family of nuclear oncoproteins represses TGF-β signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-β, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 43.449 | 6.332 | |
2000 | 36.711 | 5.999 | |
2001 | 29.247 | 5.155 | |
2002 | 28.027 | 4.956 | |
2003 | 28.284 | 4.99 | |
2004 | 25.704 | 5.002 | |
2005 | 25.262 | 4.648 | |
2006 | 23.831 | 4.889 | |
2007 | 25.228 | 5.206 | |
2008 | 25.274 | 5.631 | |
2009 | 26.21 | 6.527 | |
2010 | 25.629 | 6.426 | |
2011 | 56.8 | 25.74 | 6.681 |
2012 | 55.5 | 25.117 | 6.9 |
2013 | 52.4 | 28.254 | 6.842 |
2014 | 53.9 | 28.505 | 6.776 |
2015 | 54.6 | 27.712 | 6.29 |
2016 | 53.5 | 27.691 | 6.043 |
2017 | 54.9 | 25.137 | 5.947 |
2018 | 56.2 | 25.976 | 6.769 |
2019 | 58.7 | 24.698 | 7.114 |
2020 | 60.3 |
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