继杰 柴;Nieng Yan;Jun R. Huh;Jia Wei Wu;Wenyu Li;Bruce A. Hay;一公 施
China Association for Science and Technology;Princeton University;California Institute of Technology;Tsinghua University
发表时间:2003-11
期 刊:Nature Structural Biology
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0242574748&partnerID=8YFLogxK
The inhibitor of apoptosis protein DIAP1 inhibits Dronc-dependent cell death by ubiquitinating Dronc. The pro-death proteins Reaper, Hid and Grim (RHG) promote apoptosis by antagonizing DIAP1 function. Here we report the structural basis of Dronc recognition by DIAP1 as well as a novel mechanism by which the RHG proteins remove DIAP1-mediated downregulation of Dronc. Biochemical and structural analyses revealed that the second BIR (BIR2) domain of DIAP1 recognizes a 12-residue sequence in Dronc. This recognition is essential for DIAP1 binding to Dronc, and for targeting Dronc for ubiquitination. Notably, the Dronc-binding surface on BIR2 coincides with that required for binding to the N termini of the RHG proteins, which competitively eliminate DIAP1-mediated ubiquitination of Dronc. These observations reveal the molecular mechanisms of how DIAP1 recognizes Dronc, and more importantly, how the RHG proteins remove DIAP1-mediated ubiquitination of Dronc.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 8.539 | 2.761 | |
2000 | 6.981 | 2.556 | |
2001 | 6.543 | 2.365 | |
2002 | 6.832 | 2.636 | |
2003 | 6.992 | 2.568 | |
2004 | 7.262 | 2.696 | |
2005 | 8.122 | 2.391 | |
2006 | 8.369 | 2.297 | |
2007 | 9.705 | 2.213 | |
2008 | 9.602 | 2.034 | |
2009 | 12.133 | 2.351 | |
2010 | 12.732 | 2.608 | |
2011 | 20.4 | 11.824 | 2.517 |
2012 | 22 | 12.177 | 2.607 |
2013 | 21.4 | 11.168 | 2.452 |
2014 | 21.1 | 10.155 | 2.359 |
2015 | 23.2 | 11.288 | 2.466 |
2016 | 23.3 | 11.42 | 2.512 |
2017 | 20.9 | 10.873 | 2.539 |
2018 | 20.5 | 10.005 | 2.522 |
2019 | 19.1 | 8.792 | 2.254 |
2020 | 19.3 | 9.448 | 2.536 |
2021 | 19.7 |
相似文献推荐