Xu Zhang;Jiawei Wang;Chao Fan;Hubo Li;Honghong Sun;Shunyou Gong;有海 陈;一公 施
Tsinghua University;University of Pennsylvania;China Association for Science and Technology
发表时间:2009-1
期 刊:Nature Structural and Molecular Biology
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=58149265029&partnerID=8YFLogxK
TNFAIP8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the underlying mechanism remains enigmatic. The high-resolution crystal structure of TIPE2 reveals a previously uncharacterized fold that is different from the predicted fold of a death effector domain (DED). Strikingly, TIPE2 contains a large, hydrophobic central cavity that is poised for cofactor binding. These structural features will be important for understanding the functions of TIPE2 and other TNFAIP8 family proteins.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 8.539 | 2.761 | |
2000 | 6.981 | 2.556 | |
2001 | 6.543 | 2.365 | |
2002 | 6.832 | 2.636 | |
2003 | 6.992 | 2.568 | |
2004 | 7.262 | 2.696 | |
2005 | 8.122 | 2.391 | |
2006 | 8.369 | 2.297 | |
2007 | 9.705 | 2.213 | |
2008 | 9.602 | 2.034 | |
2009 | 12.133 | 2.351 | |
2010 | 12.732 | 2.608 | |
2011 | 20.4 | 11.824 | 2.517 |
2012 | 22 | 12.177 | 2.607 |
2013 | 21.4 | 11.168 | 2.452 |
2014 | 21.1 | 10.155 | 2.359 |
2015 | 23.2 | 11.288 | 2.466 |
2016 | 23.3 | 11.42 | 2.512 |
2017 | 20.9 | 10.873 | 2.539 |
2018 | 20.5 | 10.005 | 2.522 |
2019 | 19.1 | 8.792 | 2.254 |
2020 | 19.3 | 9.448 | 2.536 |
2021 | 19.7 |
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