Xianxin Hua;Zachary A. Miller;更 吴;一公 施;Harvey F. Lodish
Whitehead Institute for Biomedical Research;Massachusetts Institute of Technology;China Association for Science and Technology
发表时间:1999-11-9
期 刊:Proceedings of the National Academy of Sciences of the United States of America
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=0033539612&partnerID=8YFLogxK
Transforming growth factor β (TGF-β) regulates a broad range of biological processes, including cell growth, development, differentiation, and immunity. TGF-β signals through its cell surface receptor serine kinases that phosphorylate Smad2 or Smad3 proteins. Because Smad3 and its partner Smad4 bind to only 4-bp Smad binding elements (SBEs) in DNA, a central question is how specificity of TGF-β-induced transcription is achieved. We show that Smad3 selectively binds to two of the three SBEs in PE2.1, a TGF- β-inducible fragment of the plasminogen activator inhibitor-1 promoter, to mediate TGF-β-induced transcription; moreover, a precise 3-bp spacer between one SBE and the E-box, a binding site for transcription factor μE3 (TFE3), is essential for TGF-β-induced transcription. Whereas an isolated Smad3 MH1 domain binds to TFE3, TGF-β receptor-mediated phosphorylation of full-length Smad3 enhances its binding to TFE3. Together, these studies elucidate an important mechanism for specificity in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 8.52 | 2.398 | |
2000 | 7.927 | 2.452 | |
2001 | 7.189 | 2.458 | |
2002 | 7.281 | 2.498 | |
2003 | 7.129 | 2.507 | |
2004 | 7.197 | 2.617 | |
2005 | 6.94 | 2.546 | |
2006 | 6.849 | 2.45 | |
2007 | 6.867 | 2.46 | |
2008 | 7.034 | 2.431 | |
2009 | 7.025 | 2.563 | |
2010 | 6.898 | 2.541 | |
2011 | 16.8 | 6.864 | 2.642 |
2012 | 17.3 | 6.868 | 2.679 |
2013 | 17.4 | 7.073 | 2.731 |
2014 | 17.2 | 6.898 | 2.702 |
2015 | 17.8 | 6.814 | 2.677 |
2016 | 18 | 6.576 | 2.662 |
2017 | 17.1 | 6.092 | 2.675 |
2018 | 16.1 | 5.601 | 2.619 |
2019 | 15.7 | 5.165 | 2.695 |
2020 | 16.2 | 5.011 | 2.904 |
2021 | 14.4 |
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