Yu Chen;彦辉 徐;Qing Bao;Yongna Xing;Zhu Li;Zheng Lin;Jeffry B. Stock;Philip D. Jeffrey;一公 施
Princeton University
发表时间:2007-6
期 刊:Nature Structural and Molecular Biology
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=34249876632&partnerID=8YFLogxK
The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystal structure of the core domain of SV40 ST bound to the scaffolding subunit of human PP2A reveals that the ST core domain has a novel zinc-binding fold and interacts with the conserved ridge of HEAT repeats 3-6, which overlaps with the binding site for the B′ (also called PR61 or B56) regulatory subunit. ST has a lower binding affinity than B′ for the PP2A core enzyme. Consequently, ST does not efficiently displace B′ from PP2A holoenzymes in vitro. Notably, ST inhibits PP2A phosphatase activity through its N-terminal J domain. These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes.
Scopus度量
年份 | CiteScore | SJR | SNIP |
---|---|---|---|
1996 | |||
1997 | |||
1998 | |||
1999 | 8.539 | 2.761 | |
2000 | 6.981 | 2.556 | |
2001 | 6.543 | 2.365 | |
2002 | 6.832 | 2.636 | |
2003 | 6.992 | 2.568 | |
2004 | 7.262 | 2.696 | |
2005 | 8.122 | 2.391 | |
2006 | 8.369 | 2.297 | |
2007 | 9.705 | 2.213 | |
2008 | 9.602 | 2.034 | |
2009 | 12.133 | 2.351 | |
2010 | 12.732 | 2.608 | |
2011 | 20.4 | 11.824 | 2.517 |
2012 | 22 | 12.177 | 2.607 |
2013 | 21.4 | 11.168 | 2.452 |
2014 | 21.1 | 10.155 | 2.359 |
2015 | 23.2 | 11.288 | 2.466 |
2016 | 23.3 | 11.42 | 2.512 |
2017 | 20.9 | 10.873 | 2.539 |
2018 | 20.5 | 10.005 | 2.522 |
2019 | 19.1 | 8.792 | 2.254 |
2020 | 19.3 | 9.448 | 2.536 |
2021 | 19.7 |
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