Yi Wang;Yongjian Huang;Jiawei Wang;Chao Cheng;Weijiao Huang;Peilong Lu;Ya Nan Xu;鹏业 王;Nieng Yan;一公 施
Tsinghua University;CAS - Institute of Physics
发表时间:2009-11-26
期 刊:Nature
语 言:English
U R L: http://www.scopus.com/inward/record.url?scp=70849106457&partnerID=8YFLogxK
FocA is a representative member of the formate-nitrite transporter family, which transports short-chain acids in bacteria, archaea, fungi, algae and parasites. The structure and transport mechanism of the formate-nitrite transporter family remain unknown. Here we report the crystal structure of Escherichia coli FocA at 2.25 resolution. FocA forms a symmetric pentamer, with each protomer consisting of six transmembrane segments. Despite a lack of sequence homology, the overall structure of the FocA protomer closely resembles that of aquaporin and strongly argues that FocA is a channel, rather than a transporter. Structural analysis identifies potentially important channel residues, defines the channel path and reveals two constriction sites. Unlike aquaporin, FocA is impermeable to water but allows the passage of formate. A structural and biochemical investigation provides mechanistic insights into the channel activity of FocA.
Scopus度量
年份 | CiteScore | SJR | SNIP |
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1996 | |||
1997 | |||
1998 | |||
1999 | 15.599 | 7.187 | |
2000 | 11.917 | 6.857 | |
2001 | 9.874 | 6.767 | |
2002 | 10.114 | 7.184 | |
2003 | 11.384 | 7.492 | |
2004 | 11.222 | 7.538 | |
2005 | 10.333 | 7.199 | |
2006 | 9.702 | 7.156 | |
2007 | 10.344 | 7.097 | |
2008 | 13.17 | 7.307 | |
2009 | 15.185 | 8.234 | |
2010 | 16.465 | 8.204 | |
2011 | 53.1 | 17.598 | 8.667 |
2012 | 51 | 17.546 | 8.409 |
2013 | 50.9 | 19.69 | 8.511 |
2014 | 49.9 | 18.78 | 7.918 |
2015 | 51.6 | 19.669 | 8.08 |
2016 | 49.2 | 18.389 | 7.901 |
2017 | 53.7 | 17.875 | 8.679 |
2018 | 55.7 | 16.345 | 9.448 |
2019 | 51 | 14.047 | 8.546 |
2020 | 56.9 | 15.993 | 9.249 |
2021 | 56 |
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