Mucoadhesives have been perceived as an effective approach for targeting the mucosa-associated diseases, which relied on the adhesive molecules to enhance the specificity. Here, topographical binding is proposed based on the fabrication of surface pore size tunable pollen-mimetic microspheres with phase separation and electrospray technology. We proved that microspheres with large-pores (pore size of 1005 ± 448 nm) were the excellent potential candidate for the mucoadhesives, as they not only possessed better adhesion ability, but also could topographically bind cervical cancer cells. Our methods of topographical binding offered a new way of designing the mucoadhesives for treating the mucosa-associated diseases.

Feng Jiantao    Lin Ling    陈佩佩    Hua Wenda    Sun Quanmei    Ao Zhuo    Dongsheng Liu    江雷     Shutao Wang    Han   

ACS Applied Materials and Interfaces

2015

The effects of ultrasound (US), Fenton treatment, and combined US/Fenton treatment as physicochemical pretreatment processes for waste activated sludge (WAS) hydrolysis and acidification were investigated in this study. The soluble carbohydrate concentrations after US/Fenton treatment were 2.36-fold, 2.17-fold and 17.11-fold more than that obtained by the Fenton treatment, US and control tests, respectively. The corresponding concentrations of soluble protein after US/Fenton treatment were 2.43-fold, 1.47-fold and 13.37-fold more than that obtained by the Fenton treatment, US and control tests, respectively. The degree of sludge disintegration (DDCOD) for the US/Fenton treatment was 15.4%, whereas it was only 9.97% and 3.18% for the US and Fenton tests. The maximum accumulation of volatile fatty acids (VFAs) was obtained by the US/Fenton pretreatment (4594 mg COD L^-1), which presented obvious advantages over US (3485 mg COD L^-1) and Fenton (2700 mg COD L^-1) treatments. The combination of the US and Fenton treatments had a synergetic effect on improving the hydrolysis and subsequent acidification of WAS.

Bao Hongxu    江雷     Chen Chunxiao    Yang Chunxue    He Zhang-Wei    Feng Yaodong    Weiwei Cai    Wenzong Liu    王爱杰   

RSC Advances

2015

Concave microstructures such as microwells and microgrooves are widely utilized in fields such as biochips, microfluidics, and functional devices. Previously, concave microstructure fabrication was mostly based on laser etching or lithography which is either costly or of multisteps. The inkjet etching method is a direct structuring technique, but limited by its inherent transverse ink diffusion that leads to low feature resolution. Nanoimprint lithography can reach submicro and even nano ranges, whereas an elaborate template is needed. Thus, it is still a challenge to realize controllable fabrication of concave microstructures in large areas with high efficiency and resolution. Here, a template-free strategy to fabricate concave microstructures with high resolution by inkjet imprinting is provided. In this method, a sacrificial ink is inkjet-printed onto a precured viscoelastic surface and imprints its shapes to construct concave microstructures. The morphology of the microstructures could be adjusted by controlling the interaction between the two immiscible phases. The microwells/microgrooves could be used to pattern single cells and functional materials such as optical, electronic, and magnetic nanoparticles. These results will open a new pathway to fabricate concave microstructures and broaden their applications in various functional devices. A template-free strategy to fabricate concave microstructures by inkjet imprinting is demonstrated. The sacrificial ink is printed onto viscoelastic surfaces and imprints its shapes to construct the microstructures. These results will open a new pathway to fabricate concave microstructures and broaden their applications in material patterning.

Bin Bao    Jiang Jieke    Fengyu Li    Zhang Pengchao    Chen Shuoran    Qiang Yang    Shutao Wang    Bin Su    江雷     宋延林   

Advanced Functional Materials

2015

The charpy impact experiments on the 3D integrated woven spacer composites with six types of core heights are performed at room and liquid nitrogen temperatures (as low as −196 °C). Macro-fracture morphology and SEM micrographs are examined to understand the deformation and failure mechanism. The results show that the impact energy increase with the increase of the core height at both room and liquid nitrogen temperatures. Meanwhile, the impact properties at liquid nitrogen temperature have been improved significantly than that at room temperature. Moreover, at room temperature, the penetration fracture of the face sheets, the tearing and pulling out of the core fibers as well as the cracking of the matrix is the main damage and failure patterns. However, at liquid nitrogen temperature, the matrix crushing dominates the failure. Less fibers fracture and brittle fracture feature becomes more obvious. In addition, with the increase of the core heights, the damage of composites has been reduced significantly at room and liquid nitrogen temperatures.

Diansen Li    Zhao Chuang-Qi    Jiang Nan    江雷    

Fibers and Polymers

2015

The Charpy transverse impact experiments on the three-dimensional (3D) multiaxial warp knitted (MWK) composites with four fiber architectures are performed at room and liquid nitrogen temperatures (-196°C). Macrofracture morphology and scanning electron microscope (SEM) micrographs are examined to understand the impact deformation and failure mechanism. The results show that the transverse impact properties can be affected greatly by the fiber architecture and decrease significantly with the increase of 90° fibers at room and liquid nitrogen temperatures. Meanwhile, the impact energy at liquid nitrogen temperature has been improved significantly than that at room temperature. Moreover, the fiber architecture is an important parameter affecting the transverse impact damage and failure patterns of composites at room and liquid nitrogen temperatures. At liquid nitrogen temperature, the matrix solidification and interfacial bonding is enhanced significantly. However, more local microcracks occur and damage accumulation increase, especially for the materials with 90° fibers. In addition, the brittle failure feature becomes more obvious at liquid nitrogen temperature.

Diansen Li    Yao Qian-qian    Zhao Chuang-Qi    Jiang Nan    江雷    

Journal of Aerospace Engineering

2015

High-strain-rate compression experiments were performed on 3D MWK carbon/epoxy composites with different fiber architectures at room and elevated temperature using an SHPB apparatus. Macro-fracture and SEM micrographs were examined to understand the failure mechanism. The results show the dynamic properties increase with the strain rate and show a high-strain-rate sensitivity. Meanwhile, composites with [0°/0°/0°/0°] have higher properties. Moreover, composites show temperature sensitivity and the properties decrease significantly, especially for composites with [0°/90°/+45°/-45°]. The results also indicate composites take on more serious damage and failure with the strain rate. The failure of composites with [0°/0°/0°/0°] behaves in multiple delaminating, overall expansion and 0° fibers tearing. While that of composites with [0°/90°/+45°/-45°] is mainly interlaminar delaminating, local fibers tearing and fracture on different fiber layers. In addition, with increasing the temperature, the composite shows less fracture and becomes more plastic. The damage of matrix yielding, interface debonding and twisting of fibers increase significantly.

Diansen Li    陈浩然    Ge Dong-Yun    Jiang Nan    江雷    

Composites Part B: Engineering

2015

Static tensile and bending experiments are conducted on 3D MWK carbon/epoxy composites with two types of fiber architecture at room and cryogenic temperature (low as −196 ℃). Macro-Fracture morphology and SEM micrographs are examined to understand the deformation and failure mechanism. The results show that tensile stress vs. strain curves have linear elastic feature up to failure; while the load-deflection curves for composites with large fiber orientation angle have pronounced nonlinear and failure in steps. Meanwhile, tensile and bending properties at liquid nitrogen temperature have been improved significantly. Moreover, the properties can be affected greatly by the fiber architecture and these decrease with increasing fiber orientation angle at room and cryogenic temperatures. The results also show the damage and failure patterns of composites vary with the fiber architecture and temperature. The main failure for material A is 0 ° fibers fracture and matrix cracking. The failure mechanism for material B is the delamination, 90 °/+45 °/−45 ° fiber/matrix interface debonding and fibers tearing, as well as 0 ° fibers’ breakage. At cryogenic temperature, the matrix is solidified and the interfacial adhesion between fibers and matrix is enhanced significantly. However, the brittle failure becomes more obvious, more microcracks propagate and interpenetrate.

Diansen Li    Duan Hong-wei    Jiang Nan    江雷    

Fibers and Polymers

2015

In this work, a nanoporous template with a controllable channel diameter was used to simulate the oil storage ability of shale pore throats. On the basis of the wetting behaviours at the nanoscale solid-liquid interfaces, the seepage of oil in nano-channels of different diameters was examined to accurately and systematically determine the effect of the pore diameter on the oil storage capacity. The results indicated that the lower threshold for oil storage was a pore throat of 20 nm, under certain conditions. This proposed pore size threshold provides novel, evidence-based criteria for estimating the geological reserves, recoverable reserves and economically recoverable reserves of shale oil. This new understanding of shale oil processes could revolutionize the related industries.

邹才能    Jin Xu    Rukai Zhu    Gong Guangming    Sun Liang    Dai Jinxing    Meng Depeng    Wang Xiaoqi    Li Jianming    Songtao Wu    Liu Xiaodan    Wu Jun-Tao    江雷    

Scientific Reports

2015

Inspired by the biological ion channels, DNA supersandwich structures were self-assembled in diamond-shaped mica nanopores, forming highly efficient gate-like nanofluidic switch. Through asymmetric DNA modification in the mica nanopores, rectified ion transport property was observed. The results revealed that DNA, the flexible biological molecules, can also be used to build nanofluidic devices for gating and rectification function in solid-state nanopores with parallel tetrahedron structures.

Jiang Yanan    Kang Qian    Wei Guo    江雷    

Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities

2015

The advanced nanobiochips have been widely employed in diagnosing some high incidence of diseases because of their portable, low-cost, and highly sensitive features. However, the subsequent disposal of these wastes remains unexposed, probably giving rise to serious environmental pollution and health risks similar to traditional biomedical waste. Here, we have presented a TiO2 nanosisal-like coating for disposing nanobiochip waste via the photoresponsive self-cleaning features of the nanobiochip, demonstrated by the nanochips of cancer detection. Moreover, the high specificity and sensitivity of nanochips can be maintained by integrating unique nanostructured coatings (i.e., nanosisal-like coating) with specific recognition molecules (i.e., anti-EpCAM). Therefore, this study will provide a promising strategy for the design and management of practical nanobiodevices, thereby eliminating the old path "pollute first, clean up later".

Meng Jingxin    Pengchao Zhang    Zhang Feilong    Hongliang Liu    Fan Jun-Bing    刘学丽    杨高    江雷     Shutao Wang   

ACS Nano

2015