Cell | 大脑如何预判运动轨迹？新型混合敲入筛选技术优化细胞免疫疗法

来源：科研圈

用过去预测未来？大脑如何预判运动轨迹

论文标题：Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus

作者：Kenneth Kay, Jason E. Chung, Marielena Sosa, Jonathan S. Schor, Mattias P. Karlsson, Margaret C. Larkin, Daniel F. Liu, Loren M. Frank

期刊：Cell

发表时间：2020/01/30

DOI：10.1016/j.cell.2020.01.014

来源：神经现实

新方法助力细胞免疫治疗

论文标题：Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

作者：Theodore L. Roth, P. Jonathan Li, Franziska Blaeschke, Jasper F. Nies, Ryan Apathy, Cody Mowery, RubyYu, Michelle L. T. Nguyen, Youjin Lee, AnnaTruong, Joseph Hiatt, David Wu, David N.Nguyen, Daniel Goodman, Jeffrey A. Bluestone, Chun Jimmie Ye, Kole Roybal, Eric Shifrut, Alexander Marson

期刊：Cell

发表时间：2020/04/16

DOI：10.1016/j.cell.2020.03.039

来源：BioArt

都别硬撑……不论男女，压力太大都会“传”给后代

论文标题：Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids

作者：Jun Young Hong, Jaechul Lim, Fernando Carvalho, Jen Young Cho, Bharat Vaidyanathan, Shuang Yu, Charles Annicelli, W.K. Eddie Ip, Ruslan Medzhitov

期刊：Cell

发表时间：2020/03/05

数字识别码：10.1016/j.cell.2020.02.018

来源：学术经纬

机械压力下细胞如何保护核DNA？

论文标题：Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

作者：Michele M.Nava, Yekaterina A.Miroshnikova, Leah C.Biggs, Daniel B.Whitefield, FranziskaMetge, JorgeBoucas, HelenaVihinen, EijaJokitalo, XinpingLi, Juan ManuelGarcía Arcos, BerndHoffmann, RudolfMerkel, Carien M.Niessen, Kris NoelDahl, Sara A.Wickström

期刊：Cell

发表时间：2020/04/16

DOI：10.1016/j.cell.2020.03.052

来源：BioArt

华人团队《细胞》发文：50万张CT影像打造！这款AI可快速诊断新冠肺炎

论文标题：Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements and Prognosis of COVID-19 Pneumonia Using Computed Tomography

作者：Kang Zhang, Xiaohong Liu, Jun Shen, Zhihuan Li, Ye Sang, Xingwang Wu, Yunfei Cha, Wenhua Liang, Chengdi Wang, Ke Wang, Linsen Ye, Ming Gao, Zhongguo Zhou, Liang Li, Jin Wang, Zhizhong Yang, Huimin Cai, Jie Xu, Lei Yang, Wenjia Cai, Wenqin Xu, Shaoxu Wu, Wei Zhang, Shanping Jiang, Lianghong Zheng, Xuan Zhang, Li Wang, Liu Lu, Jiaming Li, Haiying Wu, Winston Wang, Oulan Li, Charlotte Zhang, Liang Liang, Tao Wu, Ruiyun Deng, Kang Wei, Yong Zhou, Ting Chen, Johnson Yiu-Nam Lau, Manson Fok, Jianxing He, Tianxin Lin, Weimin Li, Guangyu Wang

期刊：Cell

发表时间：2020/04/01

DOI：10.1016/j.cell.2020.04.045

来源：学术经纬

蛋白磷酸酶 PP2A 变构激活剂通过促进 MYBL2 去磷酸化而实现广泛的抗肿瘤活性

论文标题：Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

作者：Ken Morita, Shuning He, Radosław P. Nowak, Jinhua Wang, Mark W. Zimmerman, Cong Fu, Adam D. Durbin, Megan W. Martel, Nicole Prutsch, Nathanael S. Gray, Eric S. Fischer, A. Thomas Look

期刊：Cell

发表时间：2020/04/20

DOI：10.1016/j.cell.2020.03.051

来源：BioArt