石正丽团队从溯源到治疗揭示新冠特征学术资讯

来源：病毒学界

近日，石正丽教授团队在Nature reviews microbiology杂志发表了一篇名为“Characteristics of SARS-CoV-2 and COVID-19”的综述。

文章详细概括了COVID-19病原体SARS-Cov-2的病毒学特征，并且比较了SARS-CoV-2与人类已知病毒间的差异；此外，本章总结了目前已知的COVID-19的临床、流行病学和病理学特征，以及目前SARS-CoV-2感染的动物模型和治疗方法研究进展；并且详细讨论了SARS-CoV-2的潜在野生动物宿主和人畜共患来源。

（图一 SARS-CoV-2、SARS-CoVs和其他β冠状病毒全长基因组序列系统发育树）

（图二 COVID-19的临床特征）

（图三 SARS-CoV-2的复制及其潜在治疗靶点）

【Abstract】

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail.

来源：viramedia 病毒学界

原文链接：https://mp.weixin.qq.com/s?__biz=MzIyMzQ3NTMyMQ==&mid=2247501614&idx=1&sn=8f7bb2972d2c5e7ba53f4250e8604b90&chksm=e81f2438df68ad2ec2df638d1494c16e76f0822354981ba87be5602d5cc61a1b746a331ea888#rd

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