Intracranial atherosclerotic disease (ICAD) is a common cause of stroke with high rates of ischemic recurrence. We aimed to investigate the role of circulating exosomal microRNAs (e-miRNAs) in recurrent ischemic events in ICAD. Consecutive patients with severe ICAD undergoing intensive medical management (IMM) were prospectively enrolled. Those with recurrent ischemic events despite IMM during 6-month follow up were algorithmically matched to IMM responders. Baseline blood e-miRNA expression levels of the matched patients were measured using next generation sequencing. A total of 122 e-miRNAs were isolated from blood samples of 10 non-responders and 11 responders. Thirteen e-miRNAs predicted IMM failure with 90% sensitivity and 100% specificity. Ingenuity pathway analysis (IPA) determined 10 of the 13 e-miRNAs were significantly associated with angiogenesis-related biological functions (p < 0.025) and angiogenic factors that have been associated with recurrent ischemic events in ICAD. These e-miRNAs included miR-122-5p, miR-192-5p, miR-27b-3p, miR-16-5p, miR-486-5p, miR-30c-5p, miR-10b-5p, miR-10a-5p, miR-101-3p, and miR-24-3p. As predicted by IPA, the specific expression profiles of these 10 e-miRNAs in non-responders had a net result of inhibition of the angiogenesis-related functions and up expression of the antiangiogenic factors. This study revealed distinct expression profiles of circulating e-miRNAs in refractory ICAD, suggesting an antiangiogenic mechanism underlying IMM failure.

Hao Jiang;Juan F. Toscano;Shlee S. Song;Konrad H. Schlick;Oana M. Dumitrascu;建伟 潘;Patrick D. Lyden;Jeffrey L. Saver;Nestor R. Gonzalez

Scientific Reports

2019-12-1

The study of nonlinear sign shift for photonic qubits was presented. The nonlinear sign shift for linear optics quantum computations was realized by shifting the phases of two photons reflected by a beam splitter using an extra single photon. The study obtained the conditional phase shift of (1.05∓0.06)π. An ancilla photon and conditional detection were utilized in the implementation of nonlinear optical effect that used only linear optical elements.

Kaoru Sanaka;Thomas Jennewein;建伟 潘;Kevin Resch;Anton Zeilinger

Physical Review Letters

2004-1-9

A general approach to antinormally ordering the boson exponential quadratic operators (EQOs) is presented. By the approach, some important EQOs, including squeezed operator of one mode and two mode, linear quantum transformation operator, Bogolubov transformation operator are antinormally ordered.

Xiang Bin Wang;Yong De Zhang;建伟 潘

Chinese Physics Letters

1996

Quantum memory networks as an intermediate stage in the development of a quantum internet ¹ will enable a number of significant applications ^2-5 . To connect and entangle remote quantum memories, it is best to use photons. In previous experiments ^6-13 , entanglement of two memory nodes has been achieved via photon interference. Going beyond the state of the art by entangling many quantum nodes at a distance is highly sought after. Here, we report the entanglement of three remote quantum memories via three-photon interference. We employ laser-cooled atomic ensembles and make use of a ring cavity to enhance the overall efficiency of our memory–photon entanglement. By interfering three single photons from three separate set-ups, we create entanglement of three memories and three photons. Then, by measuring the photons and applying feed-forward, we achieve heralded entanglement between the three memories. Our experiment may be employed as a building block to construct larger and complex quantum networks ^14,15 .

Bo Jing;Xu Jie Wang;Yong Yu;Peng Fei Sun;Yan Jiang;Sheng Jun Yang;Wen Hao Jiang;Xi Yu Luo;Jun Zhang;Xiao Jiang;Xiao Hui Bao;建伟 潘

Nature Photonics

2019-3-1

We establish a mapping between a continuous-variable (CV) quantum system and a discrete quantum system of arbitrary dimension. This opens up the general possibility to perform any quantum information task with a CV system as if it were a discrete system. The Einstein-Podolsky-Rosen state is mapped onto the maximally entangled state in any finite-dimensional Hilbert space and thus can be considered as a universal resource of entanglement. An explicit example of the map and a proposal for its experimental realization are discussed.

Časlav Brukner;Myungshik S. Kim;建伟 潘;Anton Zeilinger

Physical Review A - Atomic, Molecular, and Optical Physics

2003

We report on the realization of a high-power, ultranarrow-linewidth, and frequency-locked 532 nm laser system. The laser system consists of single-pass and intra-cavity second harmonic generation of a continuous-wave Ytterbium doped fiber laser at 1064 nm in the nonlinear crystal of periodically poled lithium niobate and lithium triborate, respectively. With 47 W infrared input, 30 W green laser is generated through the type I critical phase matching in the intracavity lithium triborate crystal. The laser linewidth is measured to be on the order of sub-kHz, which is achieved by simultaneously locking the single-pass frequency doubling output onto the iodine absorption line R69 (36-1) at 532 nm. Furthermore, the phase locking between the laser system and another slave 1064 nm laser is demonstrated with relative frequency tunability being up to 10 GHz. Our results completely satisfy the requirements of 532 nm laser for quantum simulation with ultracold atoms.

Hao Ze Chen;Xiang Pei Liu;Xiao Qiong Wang;Yu Ping Wu;Yu Xuan Wang;Xing Can Yao;宇翱 陈;建伟 潘

Optics Express

2018-12-24

Intensity squeezing-i.e., photon number fluctuations below the shot-noise limit-is a fundamental aspect of quantum optics and has wide applications in quantum metrology. It was predicted in 1979 that intensity squeezing could be observed in resonance fluorescence from a two-level quantum system. However, its experimental observation in solid states was hindered by inefficiencies in generating, collecting, and detecting resonance fluorescence. Here, we report the intensity squeezing in a single-mode fiber-coupled resonance fluorescence single-photon source based on a quantum dot-micropillar system. We detect pulsed single-photon streams with 22.6% system efficiency, which show sub-shot-noise intensity fluctuation with an intensity squeezing of 0.59 dB. We estimate a corrected squeezing of 3.29 dB at the first lens. The observed intensity squeezing provides the last piece of the fundamental picture of resonance fluorescence, which can be used as a new standard for optical radiation and in scalable quantum metrology with indistinguishable single photons.

Hui Wang;Jian Qin;Si Chen;Ming Cheng Chen;Xiang You;Xing Ding;Y. H. Huo;Ying Yu;C. Schneider;Sven Höfling;Marlan Scully;Chao Yang Lu;建伟 潘

Physical Review Letters

2020-10

Backgound and Importance Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare fibrosing inflammatory process involving the dura mater. Currently, there is no consensus on the treatments for IHCP, and the usefulness of immunosuppressive agents as a first-line option remains controversial. Cerebral venous sinus occlusion (CVSO) and cerebral venous sinus thrombosis (CVST) secondary to IHCP, which may cause progressive intracranial hypertension and venous obstructive parenchymal lesions, make the diagnosis and treatment of IHCP more complicated. Methods We present a case of IHCP. We also review previous cases of IHCP with secondary CVSO/CVST and then summarize the clinical characteristics of these patients. Clinical Presentation A 52-year-old female patient with IHCP developed secondary CVST. She had a severe headache with a hyperintense lesion on computed tomography, which was considered as subarachnoid hemorrhage. Lumbar tapping with a cerebrospinal fluid test, in addition to gadolinium contrast-enhanced magnetic resonance imaging, suggested IHCP. Secondary CVST was identified by digital subtraction angiography and magnetic resonance venography. Fatal intracranial hypertension with severe neurologic deficits occurred, despite mannitol, furosemide, and corticoid therapy. After administration of intravenous pulse cyclophosphamide, she obtained complete remission. Conclusions We experienced a patient with CVST secondary to IHCP, who was successfully treated with cyclophosphamide pulse therapy. Because IHCP with secondary venous obstruction has various differential diagnoses, venography is necessary to avoid misdiagnosis. The use of immunosuppressive agents may be promising but needs further verification.

Kaiyuan Huang;Qingsheng Xu;Yuankun Ma;Renya Zhan;Jian Shen;建伟 潘

World Neurosurgery

2017-10

We report the first experimental violation of local realism by four-photon Greenberger-Horne-Zeilinger (GHZ) entanglement. In the experiment, the nonstatistical GHZ conflicts between quantum mechanics and local realism are confirmed, within the experimental accuracy, by four specific measurements of polarization correlations between four photons. In addition, our experimental results also demonstrate a strong violation of Mermin-Ardehali-Belinskii-Klyshko inequality by 76 standard deviations. Such a violation can only be attributed to genuine four-photon entanglement.

Zhi Zhao;Tao Yang;宇翱 陈;An Ning Zhang;Marek Żukowski;建伟 潘

Physical Review Letters

2003

Stimulated Raman adiabatic passage (stirap) allows efficiently transferring the populations between two discrete quantum states and has been used to prepare molecules in their rovibrational ground state. In realistic molecules, a well-resolved intermediate state is usually selected to implement the resonant stirap. Because of the complex molecular level structures, the detuned stirap always coexists with the resonant stirap and may cause unexpected interference phenomenon. However, it is generally accepted that the detuned stirap can be neglected if compared with the resonant stirap. Here we report on the first observation of interference between the resonant and detuned stirap in the adiabatic creation of Na23K40 ground-state molecules. The interference is identified by observing that the number of Feshbach molecules after a round-trip stirap oscillates as a function of the hold time, with a visibility of about 90%. This occurs even if the intermediate excited states are well resolved, and the single-photon detuning of the detuned stirap is about 1 order of magnitude larger than the linewidth of the excited state and the Rabi frequencies of the stirap lasers. Moreover, the observed interference indicates that if more than one hyperfine level of the ground state is populated, the stirap prepares a coherent superposition state among them, but not an incoherent mixed state. Further, the purity of the hyperfine levels of the created ground state can be quantitatively determined by the visibility of the oscillation.

Lan Liu;De Chao Zhang;Huan Yang;Ya Xiong Liu;Jue Nan;Jun Rui;博 赵;建伟 潘

Physical Review Letters

2019-6-25